Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Prolonged binding of radiolabeled recombinant tissue-type plasminogen activator after angioplasty and enclosed thrombolysis of the femoropopliteal arteries

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Endovascular Aneurysm Repair Treatment of Aortoiliac Aneurysms: Can Iliac Branched Devices Prevent Gluteal Claudication?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Virtual reality simulation training in a high-fidelity procedure suite: operator appraisal

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Decreased syntheses of tissue plasminogen activator antigen in users of oral contraceptives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Double-blind, controlled, multicenter study of indobufen versus placebo in patients with intermittent claudication

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Retrograde femoral angioplasty: a new technique

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
The authors measured the binding of indium-111-labeled recombinant tissue-type plasminogen activator (rt-PA) within the recanalized femoropopliteal segment after percutaneous transluminal angioplasty (PTA) and enclosed thrombolysis. In patients with long occlusions (n = 3), 91 micrograms of rt-PA was bound 1 hour after the procedure, and the half-time of the final washout curve averaged 114 hours. After PTA in patients with multiple stenoses (n = 6), 45 micrograms of rt-PA was bound, and the half-time averaged 32 hours. These values were significantly smaller than those in patients with occlusions (P <.01). In patients with a single stenosis (n = 4), 19 micrograms of rt-PA was bound, and the half-time averaged 5 hours. These values were significantly smaller than those in patients with multiple stenoses (P <.01). The progressive accumulation of rt-PA at the sites of PTA therapy is most likely related to increasing presence of fibrin with increasing lesion severity. Fibrin accumulation may be partly responsible for early failures after PTA in extensive lesions. Removal of this fibrin with enclosed thrombolysis might improve patency.
OriginalsprogEngelsk
TidsskriftJournal of Vascular and Interventional Radiology
Vol/bind3
Udgave nummer4
Sider (fra-til)627-32
Antal sider6
ISSN1051-0443
StatusUdgivet - nov. 1992

ID: 39049565