Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis

Tetsushi Kaneko; Masahiro Itoh; Yoichi Nakamura; Akira Iimura; Shogo Hayashi; Kodo Takahashi; Franca Stivala; Klaus Bendtzen; Ferdinando Nicoletti

Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis

Tetsushi Kaneko, Masahiro Itoh, Yoichi Nakamura, Akira Iimura, Shogo Hayashi, Kodo Takahashi, Franca Stivala, Klaus Bendtzen, Ferdinando Nicoletti

13 Citationer (Scopus)

Abstract

We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.

Originalsprog	Engelsk
Tidsskrift	Cytokine
Vol/bind	22
Udgave nummer	1-2
Sider (fra-til)	50-3
Antal sider	4
ISSN	1043-4666
Status	Udgivet - 1 apr. 2003

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title = "Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis",

abstract = "We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.",

author = "Tetsushi Kaneko and Masahiro Itoh and Yoichi Nakamura and Akira Iimura and Shogo Hayashi and Kodo Takahashi and Franca Stivala and Klaus Bendtzen and Ferdinando Nicoletti",

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TY - JOUR

T1 - Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis

AU - Kaneko, Tetsushi

AU - Itoh, Masahiro

AU - Nakamura, Yoichi

AU - Iimura, Akira

AU - Hayashi, Shogo

AU - Takahashi, Kodo

AU - Stivala, Franca

AU - Bendtzen, Klaus

AU - Nicoletti, Ferdinando

PY - 2003/4/1

Y1 - 2003/4/1

N2 - We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.

AB - We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.

UR - https://www.sciencedirect.com/science/article/abs/pii/S1043466603001030?via%3Dihub

UR - https://www.scopus.com/pages/publications/0141639647

M3 - Journal article

C2 - 12946105

SN - 1043-4666

VL - 22

SP - 50

EP - 53

JO - Cytokine

JF - Cytokine

IS - 1-2

ER -

Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis

Abstract

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