Abstract
We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Cytokine |
Vol/bind | 22 |
Udgave nummer | 1-2 |
Sider (fra-til) | 50-3 |
Antal sider | 4 |
ISSN | 1043-4666 |
Status | Udgivet - 1 apr. 2003 |