Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Prognostiske markører for vaegttab ved adipositasbehandling

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Integration af specialiseret palliation og onkologi

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Formodet SARS-CoV-2-dødsfald hos en tidligere rask 50-årig mand

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Akut luftvejsobstruktion grundet uerkendt akalasi efter ukompliceret vaginal fødsel

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Dansk Kvalitetsdatabase for Nyfødte (DKN) -resumé af årsrapport 2018. Indikator 9: antibiotikabehandling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Lokalanæstesitorakoskopi ved udredning af recidiverende pleuraeffusion

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Letter to the Editor: Glucocorticosteroids for Alcohol-Associated Hepatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • A V Astrup
  • B Buemann
  • C N Gluud
  • Patrick Bennett
  • T Tjur
  • N J Christensen
Vis graf over relationer
The aim of the study was to identify prognostic metabolic markers for long-term weight loss outcome in obese women. Forty female obese patients underwent a dietary intervention of 36 weeks treatment with a 4.2 MJ/d low-fat high carbohydrate diet and were followed-up two and a half years after cessation of treatment. The maximum weight loss (mean 16.2 kg. 95% CI 14.2-18.2) was positively associated to pre-treatment 24-h energy expenditure (EE) (p <0.01), fat oxidation (%) (p <0.02), plasma dihydrotestosterone (DHT) (p <0.01), and to postprandial noradrenaline concentration (p <0.04). Together these factors could explain 41% of the variation in maximum weight loss. After 36 weeks only 24-h EE and DHT had predictive power on weight loss. Weight losses in upper and lower tertiles of DHT concentrations were 17.7 kg (14.1-21.4) and 9.8 kg (6.2-13.3) (p <0.02) and the adjusted relative risk of losing <10 kg in the upper compared to the lower DHT tertile was 12% (4-32%). At two and a half years follow-up 21 patients had maintained some of the weight loss (54%), while 14 patients had maintained > 5 kg weight loss (36%). High levels of pre-treatment DHT were also associated with better weight loss at two and a half years follow-up. The study suggests that long-term weight loss outcome may be predicted by pre-treatment metabolic and hormonal factors in obese women.
Bidragets oversatte titelPrognostic markers for weight loss in the treatment of obesity
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind158
Udgave nummer32
Sider (fra-til)4513-6
Antal sider4
ISSN0041-5782
StatusUdgivet - 5 aug. 1996

    Forskningsområder

  • Adolescent, Adult, Diet, Reducing, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Prognosis, Prospective Studies, Weight Loss

ID: 38926294