Prognostiske markører for vaegttab ved adipositasbehandling

A V Astrup, B Buemann, C N Gluud, Patrick Bennett, T Tjur, N J Christensen


The aim of the study was to identify prognostic metabolic markers for long-term weight loss outcome in obese women. Forty female obese patients underwent a dietary intervention of 36 weeks treatment with a 4.2 MJ/d low-fat high carbohydrate diet and were followed-up two and a half years after cessation of treatment. The maximum weight loss (mean 16.2 kg. 95% CI 14.2-18.2) was positively associated to pre-treatment 24-h energy expenditure (EE) (p <0.01), fat oxidation (%) (p <0.02), plasma dihydrotestosterone (DHT) (p <0.01), and to postprandial noradrenaline concentration (p <0.04). Together these factors could explain 41% of the variation in maximum weight loss. After 36 weeks only 24-h EE and DHT had predictive power on weight loss. Weight losses in upper and lower tertiles of DHT concentrations were 17.7 kg (14.1-21.4) and 9.8 kg (6.2-13.3) (p <0.02) and the adjusted relative risk of losing <10 kg in the upper compared to the lower DHT tertile was 12% (4-32%). At two and a half years follow-up 21 patients had maintained some of the weight loss (54%), while 14 patients had maintained > 5 kg weight loss (36%). High levels of pre-treatment DHT were also associated with better weight loss at two and a half years follow-up. The study suggests that long-term weight loss outcome may be predicted by pre-treatment metabolic and hormonal factors in obese women.
Bidragets oversatte titelPrognostic markers for weight loss in the treatment of obesity
TidsskriftUgeskrift for Laeger
Udgave nummer32
Sider (fra-til)4513-6
Antal sider4
StatusUdgivet - 5 aug. 1996


  • Adolescent
  • Adult
  • Diet, Reducing
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Obesity
  • Prognosis
  • Prospective Studies
  • Weight Loss


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