Prognostic value of high sensitive C-reactive protein in subjects with silent myocardial ischemia

Mette  Mouridsen; Theodoros Intzilakis; Zeynep Binici; Olav Wendelboe Nielsen; Ahmad Sajadieh

doi:10.1016/j.jelectrocard.2011.11.004

Prognostic value of high sensitive C-reactive protein in subjects with silent myocardial ischemia

Mette Mouridsen, Theodoros Intzilakis, Zeynep Binici, Olav Wendelboe Nielsen, Ahmad Sajadieh

4 Citationer (Scopus)

Abstract

OBJECTIVES: The aim of this study was to evaluate the prognostic value of high sensitive C-reactive protein (CRP) in subjects with silent myocardial ischemia (SMI). DESIGN: In total, 678 healthy men and women aged 55 to 75 years with no history of cardiovascular disease or stroke were included. High-sensitive CRP and 48-hour ambulatory ECG monitoring were performed. The primary endpoint was the combined endpoint of death and myocardial infarction. RESULTS: The median follow-up time was 76 months. Seventy-seven subjects (11.4%) had SMI. The combined endpoint occurred in 26% of the subjects with SMI and 14% of the subjects without SMI (P = .005). SMI had a poor prognosis in the group with an elevated CRP ≥3.0 μg/mL (hazard ratio, 3.46; 95% confidence interval, 1.67-7.16; P = .001) compared with the group of subjects with SMI and a low CRP

Originalsprog	Engelsk
Tidsskrift	Journal of Electrocardiology
Vol/bind	45
Udgave nummer	3
Sider (fra-til)	260-264
ISSN	0022-0736
DOI	https://doi.org/10.1016/j.jelectrocard.2011.11.004
Status	Udgivet - 2012

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10.1016/j.jelectrocard.2011.11.004

Citationsformater

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title = "Prognostic value of high sensitive C-reactive protein in subjects with silent myocardial ischemia",

abstract = "OBJECTIVES: The aim of this study was to evaluate the prognostic value of high sensitive C-reactive protein (CRP) in subjects with silent myocardial ischemia (SMI). DESIGN: In total, 678 healthy men and women aged 55 to 75 years with no history of cardiovascular disease or stroke were included. High-sensitive CRP and 48-hour ambulatory ECG monitoring were performed. The primary endpoint was the combined endpoint of death and myocardial infarction. RESULTS: The median follow-up time was 76 months. Seventy-seven subjects (11.4%) had SMI. The combined endpoint occurred in 26% of the subjects with SMI and 14% of the subjects without SMI (P = .005). SMI had a poor prognosis in the group with an elevated CRP ≥3.0 μg/mL (hazard ratio, 3.46; 95% confidence interval, 1.67-7.16; P = .001) compared with the group of subjects with SMI and a low CRP ",

author = "Mette Mouridsen and Theodoros Intzilakis and Zeynep Binici and Nielsen, {Olav Wendelboe} and Ahmad Sajadieh",

note = "Copyright {\textcopyright} 2011. Published by Elsevier Inc.",

year = "2012",

doi = "10.1016/j.jelectrocard.2011.11.004",

language = "English",

volume = "45",

pages = "260--264",

journal = "Journal of Electrocardiology",

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TY - JOUR

T1 - Prognostic value of high sensitive C-reactive protein in subjects with silent myocardial ischemia

AU - Mouridsen, Mette

AU - Intzilakis, Theodoros

AU - Binici, Zeynep

AU - Nielsen, Olav Wendelboe

AU - Sajadieh, Ahmad

PY - 2012

Y1 - 2012

N2 - OBJECTIVES: The aim of this study was to evaluate the prognostic value of high sensitive C-reactive protein (CRP) in subjects with silent myocardial ischemia (SMI). DESIGN: In total, 678 healthy men and women aged 55 to 75 years with no history of cardiovascular disease or stroke were included. High-sensitive CRP and 48-hour ambulatory ECG monitoring were performed. The primary endpoint was the combined endpoint of death and myocardial infarction. RESULTS: The median follow-up time was 76 months. Seventy-seven subjects (11.4%) had SMI. The combined endpoint occurred in 26% of the subjects with SMI and 14% of the subjects without SMI (P = .005). SMI had a poor prognosis in the group with an elevated CRP ≥3.0 μg/mL (hazard ratio, 3.46; 95% confidence interval, 1.67-7.16; P = .001) compared with the group of subjects with SMI and a low CRP

AB - OBJECTIVES: The aim of this study was to evaluate the prognostic value of high sensitive C-reactive protein (CRP) in subjects with silent myocardial ischemia (SMI). DESIGN: In total, 678 healthy men and women aged 55 to 75 years with no history of cardiovascular disease or stroke were included. High-sensitive CRP and 48-hour ambulatory ECG monitoring were performed. The primary endpoint was the combined endpoint of death and myocardial infarction. RESULTS: The median follow-up time was 76 months. Seventy-seven subjects (11.4%) had SMI. The combined endpoint occurred in 26% of the subjects with SMI and 14% of the subjects without SMI (P = .005). SMI had a poor prognosis in the group with an elevated CRP ≥3.0 μg/mL (hazard ratio, 3.46; 95% confidence interval, 1.67-7.16; P = .001) compared with the group of subjects with SMI and a low CRP

U2 - 10.1016/j.jelectrocard.2011.11.004

DO - 10.1016/j.jelectrocard.2011.11.004

M3 - Journal article

C2 - 22217366

SN - 0022-0736

VL - 45

SP - 260

EP - 264

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 3

ER -

Prognostic value of high sensitive C-reactive protein in subjects with silent myocardial ischemia

Abstract

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