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Prognostic value of biochemical variables for survival after surgery for metastatic bone disease of the extremities

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@article{82b7c614f7fd4c57b6c46f394d8811b0,
title = "Prognostic value of biochemical variables for survival after surgery for metastatic bone disease of the extremities",
abstract = "BACKGROUND AND OBJECTIVE: Prediction of survival in patients having surgery for metastatic bone disease in the extremities (MBDex) has been of interest in more than two decades. Hitherto no consensus on the value of biochemical variables has been achieved. Our purpose was (1) to investigate if standard biochemical variables have independent prognostic value for survival after surgery for MBDex and (2) to identify optimal prognostic cut off values for survival of biochemical variables.METHODS: In a consecutive cohort of 270 patients having surgery for MBDex, we measured preoperative biochemical variables: hemoglobin, alkaline phosphatase, C-reactive protein and absolute, neutrophil and lymphocyte count. ROC curve analyses were performed to identify optimal cut off levels. Independent prognostic factors for variables were addressed with multiple Cox regression analyses.RESULTS: Optimal cut off levels were identified as: hemoglobin 7.45 mmol/L, absolute lymphocyte count 8.5 × 109/L, neutrophil 5.68 × 109/L, lymphocyte 1.37 × 109/L, C-reactive protein 22.5 mg/L, and alkaline phosphatase 129 U/L. Regression analyses found alkaline phosphatase (HR 2.49) and neutrophil count (HR 2.49) to be independent prognostic factors.CONCLUSIONS: We found neutrophil count and alkaline phosphatase to be independent prognostic variables in predicting survival in patients after surgery for MBDex.",
keywords = "Adult, Aged, Aged, 80 and over, Alkaline Phosphatase, Biomarkers, Bone Neoplasms, C-Reactive Protein, Cohort Studies, Extremities, Female, Hemoglobins, Humans, Leukocyte Count, Male, Middle Aged, Neutrophils, Prognosis, Regression Analysis, Young Adult, Journal Article",
author = "S{\o}rensen, {Michala Skovlund} and Hovgaard, {Thea Bechman} and Klaus Hinds{\o} and Petersen, {Michael M{\o}rk}",
note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2017",
month = mar,
doi = "10.1002/jso.24537",
language = "English",
volume = "115",
pages = "442--448",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Prognostic value of biochemical variables for survival after surgery for metastatic bone disease of the extremities

AU - Sørensen, Michala Skovlund

AU - Hovgaard, Thea Bechman

AU - Hindsø, Klaus

AU - Petersen, Michael Mørk

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2017/3

Y1 - 2017/3

N2 - BACKGROUND AND OBJECTIVE: Prediction of survival in patients having surgery for metastatic bone disease in the extremities (MBDex) has been of interest in more than two decades. Hitherto no consensus on the value of biochemical variables has been achieved. Our purpose was (1) to investigate if standard biochemical variables have independent prognostic value for survival after surgery for MBDex and (2) to identify optimal prognostic cut off values for survival of biochemical variables.METHODS: In a consecutive cohort of 270 patients having surgery for MBDex, we measured preoperative biochemical variables: hemoglobin, alkaline phosphatase, C-reactive protein and absolute, neutrophil and lymphocyte count. ROC curve analyses were performed to identify optimal cut off levels. Independent prognostic factors for variables were addressed with multiple Cox regression analyses.RESULTS: Optimal cut off levels were identified as: hemoglobin 7.45 mmol/L, absolute lymphocyte count 8.5 × 109/L, neutrophil 5.68 × 109/L, lymphocyte 1.37 × 109/L, C-reactive protein 22.5 mg/L, and alkaline phosphatase 129 U/L. Regression analyses found alkaline phosphatase (HR 2.49) and neutrophil count (HR 2.49) to be independent prognostic factors.CONCLUSIONS: We found neutrophil count and alkaline phosphatase to be independent prognostic variables in predicting survival in patients after surgery for MBDex.

AB - BACKGROUND AND OBJECTIVE: Prediction of survival in patients having surgery for metastatic bone disease in the extremities (MBDex) has been of interest in more than two decades. Hitherto no consensus on the value of biochemical variables has been achieved. Our purpose was (1) to investigate if standard biochemical variables have independent prognostic value for survival after surgery for MBDex and (2) to identify optimal prognostic cut off values for survival of biochemical variables.METHODS: In a consecutive cohort of 270 patients having surgery for MBDex, we measured preoperative biochemical variables: hemoglobin, alkaline phosphatase, C-reactive protein and absolute, neutrophil and lymphocyte count. ROC curve analyses were performed to identify optimal cut off levels. Independent prognostic factors for variables were addressed with multiple Cox regression analyses.RESULTS: Optimal cut off levels were identified as: hemoglobin 7.45 mmol/L, absolute lymphocyte count 8.5 × 109/L, neutrophil 5.68 × 109/L, lymphocyte 1.37 × 109/L, C-reactive protein 22.5 mg/L, and alkaline phosphatase 129 U/L. Regression analyses found alkaline phosphatase (HR 2.49) and neutrophil count (HR 2.49) to be independent prognostic factors.CONCLUSIONS: We found neutrophil count and alkaline phosphatase to be independent prognostic variables in predicting survival in patients after surgery for MBDex.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alkaline Phosphatase

KW - Biomarkers

KW - Bone Neoplasms

KW - C-Reactive Protein

KW - Cohort Studies

KW - Extremities

KW - Female

KW - Hemoglobins

KW - Humans

KW - Leukocyte Count

KW - Male

KW - Middle Aged

KW - Neutrophils

KW - Prognosis

KW - Regression Analysis

KW - Young Adult

KW - Journal Article

U2 - 10.1002/jso.24537

DO - 10.1002/jso.24537

M3 - Journal article

C2 - 28019011

VL - 115

SP - 442

EP - 448

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 4

ER -

ID: 52757253