Prognostic impact of clinician-based interpretation of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography reports obtained in patients with newly diagnosed diffuse large B-cell lymphoma

Karen J Mylam, Tarec Christoffer El-Galaly, Martin Hutchings, Peter Brown, Bodil Himmelstrup, Oke Gerke, Dorte Gillstrøm, Ida Blok Sillesen, Lars Munksgaard, Bjarne B Pedersen, Ilse Christiansen, Paw Jensen, Anne Louise Nielsen, Lars M Pedersen

    8 Citationer (Scopus)

    Abstract

    The aim of this study was to evaluate the prognostic value of clinician interpretation of positron emission tomography/computed tomography (PET/CT) reports at mid-therapy, interim PET (I-PET) and after the end of first-line therapy (E-PET) in patients with diffuse large B-cell lymphoma (DLBCL). Four hundred and thirty patients were enrolled in this study comprising a total of 617 PET reports. Each report was evaluated by three expert hematologists randomly selected from a panel of nine. Reports were labeled positive or negative if all three interpreters agreed. All others were considered indeterminate. Indeterminate reports accounted for 59% of I-PET and 49% of E-PET reports. Two-year overall survival (OS) for patients with a positive, indeterminate and negative I-PET was 58%, 87% and 89% (p
    OriginalsprogEngelsk
    TidsskriftLeukemia and Lymphoma
    Vol/bind55
    Udgave nummer7
    Sider (fra-til)1563-69
    ISSN1042-8194
    DOI
    StatusUdgivet - 2014

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