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Prognostic and predictive value of YKL-40 in stage IIB-III melanoma

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Krogh, M, Christensen, I, Bouwhuis, M, Johansen, JS, Nørgaard, P, Schmidt, H, Hansson, J, Suciu, S, Eggermont, AMM, Bastholt, L & Nordic Melanoma Group and EORTC Melanoma Group 2016, 'Prognostic and predictive value of YKL-40 in stage IIB-III melanoma' Melanoma Research, bind 26, nr. 4, s. 367-76. https://doi.org/10.1097/CMR.0000000000000237

APA

CBE

Krogh M, Christensen I, Bouwhuis M, Johansen JS, Nørgaard P, Schmidt H, Hansson J, Suciu S, Eggermont AMM, Bastholt L, Nordic Melanoma Group and EORTC Melanoma Group. 2016. Prognostic and predictive value of YKL-40 in stage IIB-III melanoma. Melanoma Research. 26(4):367-76. https://doi.org/10.1097/CMR.0000000000000237

MLA

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Author

Krogh, Merete ; Christensen, Ib ; Bouwhuis, Marna ; Johansen, Julia S ; Nørgaard, Peter ; Schmidt, Henrik ; Hansson, Johan ; Suciu, Stefan ; Eggermont, Alexander M M ; Bastholt, Lars ; Nordic Melanoma Group and EORTC Melanoma Group. / Prognostic and predictive value of YKL-40 in stage IIB-III melanoma. I: Melanoma Research. 2016 ; Bind 26, Nr. 4. s. 367-76.

Bibtex

@article{8c872e1a944645b28062b2a9ea75b4c4,
title = "Prognostic and predictive value of YKL-40 in stage IIB-III melanoma",
abstract = "This study investigates the prognostic and predictive value of YKL-40 in stage IIB-III melanoma patients who were randomized to adjuvant interferon α-2b (IFN) or observation. Serum YKL-40 was determined postoperatively in patients from the Nordic IFN Trial (n=602), EORTC 18952 (n=246), and EORTC 18991 (n=386) (EORTC, European Organisation for Research and Treatment of Cancer). YKL-40 protein expression was determined in 300 tissue sections of primary melanoma or lymph node metastases from 204 Danish patients from the Nordic IFN Trial. Multivariate Cox analysis (including sex, age, stage, ulceration, YKL-40) showed that elevated baseline YKL-40 level was associated with shorter overall survival (OS) in observation groups from the Nordic IFN Trial and EORTC 18952 [hazard ratio (HR)=1.33; 95{\%} confidence interval (CI) 1.01-1.74; P=0.04], but not in the interferon groups (1-year IFN: HR=0.97; 95{\%} CI 0.76-1.25; P=0.83; 2-years IFN: HR=1.06; 95{\%} CI 0.83-1.34; P=0.64). During follow-up, increases in YKL-40 were significantly associated with shorter OS, but not with recurrence-free survival in univariate analysis. YKL-40 expression was stronger in tumor-associated macrophages than melanoma cells in primary melanoma. High YKL-40 expression in macrophages in lymph node metastases was associated with shorter OS in the observation group (HR=2.76; 95{\%} CI: 1.13-6.76, P=0.02), but not in the interferon-treated groups. YKL-40 was an independent prognostic biomarker of OS in melanoma patients stage IIB-III. High serum YKL-40 in poor-prognosis patients may originate from macrophages in the tumor microenvironment and the melanoma cells. Furthermore, we hypothesize that elevated serum YKL-40 after surgery may predict the efficacy of adjuvant IFN treatment.",
keywords = "Journal Article",
author = "Merete Krogh and Ib Christensen and Marna Bouwhuis and Johansen, {Julia S} and Peter N{\o}rgaard and Henrik Schmidt and Johan Hansson and Stefan Suciu and Eggermont, {Alexander M M} and Lars Bastholt and {Nordic Melanoma Group and EORTC Melanoma Group}",
year = "2016",
month = "8",
doi = "10.1097/CMR.0000000000000237",
language = "English",
volume = "26",
pages = "367--76",
journal = "Melanoma Research",
issn = "0960-8931",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Prognostic and predictive value of YKL-40 in stage IIB-III melanoma

AU - Krogh, Merete

AU - Christensen, Ib

AU - Bouwhuis, Marna

AU - Johansen, Julia S

AU - Nørgaard, Peter

AU - Schmidt, Henrik

AU - Hansson, Johan

AU - Suciu, Stefan

AU - Eggermont, Alexander M M

AU - Bastholt, Lars

AU - Nordic Melanoma Group and EORTC Melanoma Group

PY - 2016/8

Y1 - 2016/8

N2 - This study investigates the prognostic and predictive value of YKL-40 in stage IIB-III melanoma patients who were randomized to adjuvant interferon α-2b (IFN) or observation. Serum YKL-40 was determined postoperatively in patients from the Nordic IFN Trial (n=602), EORTC 18952 (n=246), and EORTC 18991 (n=386) (EORTC, European Organisation for Research and Treatment of Cancer). YKL-40 protein expression was determined in 300 tissue sections of primary melanoma or lymph node metastases from 204 Danish patients from the Nordic IFN Trial. Multivariate Cox analysis (including sex, age, stage, ulceration, YKL-40) showed that elevated baseline YKL-40 level was associated with shorter overall survival (OS) in observation groups from the Nordic IFN Trial and EORTC 18952 [hazard ratio (HR)=1.33; 95% confidence interval (CI) 1.01-1.74; P=0.04], but not in the interferon groups (1-year IFN: HR=0.97; 95% CI 0.76-1.25; P=0.83; 2-years IFN: HR=1.06; 95% CI 0.83-1.34; P=0.64). During follow-up, increases in YKL-40 were significantly associated with shorter OS, but not with recurrence-free survival in univariate analysis. YKL-40 expression was stronger in tumor-associated macrophages than melanoma cells in primary melanoma. High YKL-40 expression in macrophages in lymph node metastases was associated with shorter OS in the observation group (HR=2.76; 95% CI: 1.13-6.76, P=0.02), but not in the interferon-treated groups. YKL-40 was an independent prognostic biomarker of OS in melanoma patients stage IIB-III. High serum YKL-40 in poor-prognosis patients may originate from macrophages in the tumor microenvironment and the melanoma cells. Furthermore, we hypothesize that elevated serum YKL-40 after surgery may predict the efficacy of adjuvant IFN treatment.

AB - This study investigates the prognostic and predictive value of YKL-40 in stage IIB-III melanoma patients who were randomized to adjuvant interferon α-2b (IFN) or observation. Serum YKL-40 was determined postoperatively in patients from the Nordic IFN Trial (n=602), EORTC 18952 (n=246), and EORTC 18991 (n=386) (EORTC, European Organisation for Research and Treatment of Cancer). YKL-40 protein expression was determined in 300 tissue sections of primary melanoma or lymph node metastases from 204 Danish patients from the Nordic IFN Trial. Multivariate Cox analysis (including sex, age, stage, ulceration, YKL-40) showed that elevated baseline YKL-40 level was associated with shorter overall survival (OS) in observation groups from the Nordic IFN Trial and EORTC 18952 [hazard ratio (HR)=1.33; 95% confidence interval (CI) 1.01-1.74; P=0.04], but not in the interferon groups (1-year IFN: HR=0.97; 95% CI 0.76-1.25; P=0.83; 2-years IFN: HR=1.06; 95% CI 0.83-1.34; P=0.64). During follow-up, increases in YKL-40 were significantly associated with shorter OS, but not with recurrence-free survival in univariate analysis. YKL-40 expression was stronger in tumor-associated macrophages than melanoma cells in primary melanoma. High YKL-40 expression in macrophages in lymph node metastases was associated with shorter OS in the observation group (HR=2.76; 95% CI: 1.13-6.76, P=0.02), but not in the interferon-treated groups. YKL-40 was an independent prognostic biomarker of OS in melanoma patients stage IIB-III. High serum YKL-40 in poor-prognosis patients may originate from macrophages in the tumor microenvironment and the melanoma cells. Furthermore, we hypothesize that elevated serum YKL-40 after surgery may predict the efficacy of adjuvant IFN treatment.

KW - Journal Article

U2 - 10.1097/CMR.0000000000000237

DO - 10.1097/CMR.0000000000000237

M3 - Journal article

VL - 26

SP - 367

EP - 376

JO - Melanoma Research

JF - Melanoma Research

SN - 0960-8931

IS - 4

ER -

ID: 49700392