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Prognosis of Allogeneic Haematopoietic Stem Cell Recipients Admitted to the Intensive Care Unit: A Retrospective, Single-Centre Study

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@article{9e81bf11d5814726abbfd9284139f72d,
title = "Prognosis of Allogeneic Haematopoietic Stem Cell Recipients Admitted to the Intensive Care Unit: A Retrospective, Single-Centre Study",
abstract = "BACKGROUND: Allogeneic haematopoietic stem cell transplantation (HSCT) is a procedure with inherent complications and intensive care may be necessary. We evaluated the short- and long-term outcomes of the HSCT recipients requiring admission to the intensive care unit (ICU).METHODS: We retrospectively examined the outcome of 54 adult haematological HSCT recipients admitted to the ICU at the University Hospital Rigshospitalet between January 2007 and March 2012.RESULTS: The overall in-ICU, in-hospital, 6-month and 1-year mortality rates were 46.3, 75.9, 79.6 and 86.5%, respectively. Mechanical ventilation had a statistically significant effect on in-ICU (p = 0.02), 6-month (p = 0.049) and 1-year (p = 0.014) mortality. Renal replacement therapy also had a statistically significant effect on in-hospital (p = 0.038) and 6-month (p = 0.026) mortality. Short ICU admissions, i.e. <10 days, had a statistically significant positive effect on in-hospital, 6-month and 1-year mortality (all p < 0.001). The SAPS II, APACHE II and SOFA scoring systems grossly underestimated the actual in-hospital mortality observed for these patients.CONCLUSION: The poor prognosis of critically ill HSCT recipients admitted to the ICU was confirmed in our study. Mechanical ventilation, renal replacement therapy and an ICU admission of ≥10 days were each risk factors for mortality in the first year after ICU admission.",
keywords = "Adolescent, Adult, Aged, Critical Illness, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Hospital Mortality, Hospitals, University, Humans, Intensive Care Units, Lymphoma, Male, Middle Aged, Prognosis, Renal Replacement Therapy, Retrospective Studies, Transplantation, Homologous, Young Adult, Journal Article",
author = "Lindgaard, {Sidsel Christy} and Jonas Nielsen and Anders Lindmark and Henrik Sengel{\o}v",
note = "{\textcopyright} 2015 S. Karger AG, Basel.",
year = "2016",
doi = "10.1159/000440937",
language = "English",
volume = "135",
pages = "72--8",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S./Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - Prognosis of Allogeneic Haematopoietic Stem Cell Recipients Admitted to the Intensive Care Unit

T2 - A Retrospective, Single-Centre Study

AU - Lindgaard, Sidsel Christy

AU - Nielsen, Jonas

AU - Lindmark, Anders

AU - Sengeløv, Henrik

N1 - © 2015 S. Karger AG, Basel.

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Allogeneic haematopoietic stem cell transplantation (HSCT) is a procedure with inherent complications and intensive care may be necessary. We evaluated the short- and long-term outcomes of the HSCT recipients requiring admission to the intensive care unit (ICU).METHODS: We retrospectively examined the outcome of 54 adult haematological HSCT recipients admitted to the ICU at the University Hospital Rigshospitalet between January 2007 and March 2012.RESULTS: The overall in-ICU, in-hospital, 6-month and 1-year mortality rates were 46.3, 75.9, 79.6 and 86.5%, respectively. Mechanical ventilation had a statistically significant effect on in-ICU (p = 0.02), 6-month (p = 0.049) and 1-year (p = 0.014) mortality. Renal replacement therapy also had a statistically significant effect on in-hospital (p = 0.038) and 6-month (p = 0.026) mortality. Short ICU admissions, i.e. <10 days, had a statistically significant positive effect on in-hospital, 6-month and 1-year mortality (all p < 0.001). The SAPS II, APACHE II and SOFA scoring systems grossly underestimated the actual in-hospital mortality observed for these patients.CONCLUSION: The poor prognosis of critically ill HSCT recipients admitted to the ICU was confirmed in our study. Mechanical ventilation, renal replacement therapy and an ICU admission of ≥10 days were each risk factors for mortality in the first year after ICU admission.

AB - BACKGROUND: Allogeneic haematopoietic stem cell transplantation (HSCT) is a procedure with inherent complications and intensive care may be necessary. We evaluated the short- and long-term outcomes of the HSCT recipients requiring admission to the intensive care unit (ICU).METHODS: We retrospectively examined the outcome of 54 adult haematological HSCT recipients admitted to the ICU at the University Hospital Rigshospitalet between January 2007 and March 2012.RESULTS: The overall in-ICU, in-hospital, 6-month and 1-year mortality rates were 46.3, 75.9, 79.6 and 86.5%, respectively. Mechanical ventilation had a statistically significant effect on in-ICU (p = 0.02), 6-month (p = 0.049) and 1-year (p = 0.014) mortality. Renal replacement therapy also had a statistically significant effect on in-hospital (p = 0.038) and 6-month (p = 0.026) mortality. Short ICU admissions, i.e. <10 days, had a statistically significant positive effect on in-hospital, 6-month and 1-year mortality (all p < 0.001). The SAPS II, APACHE II and SOFA scoring systems grossly underestimated the actual in-hospital mortality observed for these patients.CONCLUSION: The poor prognosis of critically ill HSCT recipients admitted to the ICU was confirmed in our study. Mechanical ventilation, renal replacement therapy and an ICU admission of ≥10 days were each risk factors for mortality in the first year after ICU admission.

KW - Adolescent

KW - Adult

KW - Aged

KW - Critical Illness

KW - Female

KW - Graft vs Host Disease

KW - Hematopoietic Stem Cell Transplantation

KW - Hematopoietic Stem Cells

KW - Hospital Mortality

KW - Hospitals, University

KW - Humans

KW - Intensive Care Units

KW - Lymphoma

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Renal Replacement Therapy

KW - Retrospective Studies

KW - Transplantation, Homologous

KW - Young Adult

KW - Journal Article

U2 - 10.1159/000440937

DO - 10.1159/000440937

M3 - Journal article

C2 - 26512978

VL - 135

SP - 72

EP - 78

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 2

ER -

ID: 49630947