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Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets

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  • Rajesh Kumar
  • Albert Salehi
  • Jens F Rehfeld
  • Peter Höglund
  • Erik Lindström
  • Rolf Håkanson
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Proghrelin, produced by the ghrelin (A-like) cells of the gastric mucosa, gives rise to cleavage products, including desacyl ghrelin, acyl ghrelin and obestatin. The products are thought to be secreted concomitantly. In an earlier study we found acyl ghrelin and obestatin, but not desacyl ghrelin, to suppress the release of hormones from isolated islets of mouse and rat pancreas.
OriginalsprogEngelsk
TidsskriftRegulatory Peptides
Vol/bind164
Udgave nummer2-3
Sider (fra-til)65-70
Antal sider6
ISSN0167-0115
DOI
StatusUdgivet - 24 sep. 2010

ID: 31046564