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Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

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  • Andrea Tura
  • Eleonora Grespan
  • Christian S. Göbl
  • Robert W. Koivula
  • Paul W. Franks
  • Ewan R. Pearson
  • Mark Walker
  • Ian M. Forgie
  • Giuseppe N. Giordano
  • Imre Pavo
  • Hartmut Ruetten
  • Emmanouil T. Dermitzakis
  • Mark I. McCarthy
  • Oluf Pedersen
  • Jochen M. Schwenk
  • Jerzy Adamski
  • Federico De Masi
  • Konstantinos D. Tsirigos
  • Søren Brunak
  • Ana Viñuela
  • Anubha Mahajan
  • Timothy J. McDonald
  • Tarja Kokkola
  • Jagadish Vangipurapu
  • Henna Cederberg
  • Markku Laakso
  • Femke Rutters
  • Petra J.M. Elders
  • Anitra D.M. Koopman
  • Joline W. Beulens
  • Martin Ridderstråle
  • Tue H. Hansen
  • Kristine H. Allin
  • Torben Hansen
  • Henrik Vestergaard
  • Andrea Mari
  • IMI-DIRECT consortium
Vis graf over relationer

Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.

OriginalsprogEngelsk
TidsskriftDiabetes
Vol/bind70
Udgave nummer9
Sider (fra-til)2092-2106
Antal sider15
ISSN0012-1797
DOI
StatusUdgivet - 1 sep. 2021

Bibliografisk note

Publisher Copyright:
© 2021 by the American Diabetes Association.

ID: 68816395