@article{c3d06bd7c5fe495180330d477a772cff,
title = "Processing of pro-opiomelanocortin-derived amidated joining peptide and glycine-extended precursor in monkey pituitary",
abstract = "The molecular forms of proopiomelanocortin (POMC) derived amidated and C-terminal glycine-extended joining peptide from monkey (Macaca mulatta) pituitary were determined. The predominant forms of joining peptide found were the low molecular peptides POMC(76-105) and POMC(76-106), respectively. Significant amounts of N-terminally truncated POMC(78-105) and POMC(78-106) were also detected in the posterior-intermediate lobe. No N-terminal extended forms were detected. The relative amount of amidated joining peptide to total joining peptide was 6-35\%. It is concluded that not only is the primary sequence of monkey and human POMC extremely conserved, but also the processing patterns are similar. The monkey therefore serves as a suitable model for studying regulation of the processing of POMC and the hypothalamus-pituitary-adrenal axis in man.",
keywords = "Amino Acid Sequence, Amino Acids, Animals, Chromatography, High Pressure Liquid, Glycine, Kinetics, Macaca mulatta, Molecular Sequence Data, Peptide Fragments, Pituitary Gland, Pro-Opiomelanocortin, Radioimmunoassay",
author = "M Fenger",
year = "1991",
language = "English",
volume = "124",
pages = "190--4",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",
}