Probing complex morphologies at decreasing diffusion times using Diffusion-weighted MR Spectroscopy

Nathalie Just; Samo Lasič; Ditte Bentsen Christensen; Julien  Julien Valette; Tim B Dyrby; Hartwig R. Siebner

Probing complex morphologies at decreasing diffusion times using Diffusion-weighted MR Spectroscopy

Nathalie Just
, Samo Lasič
, Ditte Bentsen Christensen
, Julien Julien Valette
, Tim B Dyrby
, Hartwig R. Siebner

Abstract

Metabolite diffusion provide the unique ability to study the intracellular environment of specific cell types of the brain. Multiple studies suggest that the diffusivity along dendrites and axons is time dependent due to variations in diameter. We explore the signal due to such effects in Monte Carlo simulations in settings feasible for preclinical PGSE measurements and find that time dependent kurtosis, but not diffusivity provide the most potent source of contrast to this effect. We observe similar effects of intraneuronal NAA diffusion in rat.

Originalsprog	Engelsk
Publikationsdato	2022
Status	Udgivet - 2022
Begivenhed	Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting - London, Englnd, UK Varighed: 7 maj 2022 → 12 maj 2022 https://www.ismrm.org/22m/

Konference

Konference	Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting
Lokation	London, Englnd, UK
Periode	07/05/2022 → 12/05/2022
Internetadresse	https://www.ismrm.org/22m/

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Citationsformater

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title = "Probing complex morphologies at decreasing diffusion times using Diffusion-weighted MR Spectroscopy",

abstract = "Metabolite diffusion provide the unique ability to study the intracellular environment of specific cell types of the brain. Multiple studies suggest that the diffusivity along dendrites and axons is time dependent due to variations in diameter. We explore the signal due to such effects in Monte Carlo simulations in settings feasible for preclinical PGSE measurements and find that time dependent kurtosis, but not diffusivity provide the most potent source of contrast to this effect. We observe similar effects of intraneuronal NAA diffusion in rat.",

author = "Nathalie Just and Samo Lasi{\v c} and Christensen, \{Ditte Bentsen\} and \{Julien Valette\}, Julien and Dyrby, \{Tim B\} and Siebner, \{Hartwig R.\}",

year = "2022",

language = "English",

note = "Joint Annual Meeting ISMRM-ESMRMB \& ISMRT 31st Annual Meeting, ISMRM ; Conference date: 07-05-2022 Through 12-05-2022",

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TY - CONF

T1 - Probing complex morphologies at decreasing diffusion times using Diffusion-weighted MR Spectroscopy

AU - Just, Nathalie

AU - Lasič, Samo

AU - Christensen, Ditte Bentsen

AU - Julien Valette, Julien

AU - Dyrby, Tim B

AU - Siebner, Hartwig R.

PY - 2022

Y1 - 2022

N2 - Metabolite diffusion provide the unique ability to study the intracellular environment of specific cell types of the brain. Multiple studies suggest that the diffusivity along dendrites and axons is time dependent due to variations in diameter. We explore the signal due to such effects in Monte Carlo simulations in settings feasible for preclinical PGSE measurements and find that time dependent kurtosis, but not diffusivity provide the most potent source of contrast to this effect. We observe similar effects of intraneuronal NAA diffusion in rat.

AB - Metabolite diffusion provide the unique ability to study the intracellular environment of specific cell types of the brain. Multiple studies suggest that the diffusivity along dendrites and axons is time dependent due to variations in diameter. We explore the signal due to such effects in Monte Carlo simulations in settings feasible for preclinical PGSE measurements and find that time dependent kurtosis, but not diffusivity provide the most potent source of contrast to this effect. We observe similar effects of intraneuronal NAA diffusion in rat.

UR - https://archive.ismrm.org/2022/0980.html

M3 - Poster

T2 - Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting

Y2 - 7 May 2022 through 12 May 2022

ER -

Probing complex morphologies at decreasing diffusion times using Diffusion-weighted MR Spectroscopy

Abstract

Konference

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Citationsformater