TY - JOUR
T1 - Principal components analysis of atopy-related traits in a random sample of children
AU - Thomsen, Simon Francis
AU - Backer, Vibeke
PY - 2011
Y1 - 2011
N2 - Aim. To study the relationship between atopy-related traits in a random sample of children. Methods. A total of 1007 randomly selected children, 7-17 years of age, from Copenhagen, Denmark were studied. The children were interviewed about symptoms of atopic diseases, and skin test reactivity, serum total IgE, lung function, and airway responsiveness were measured. Principal components analysis was performed in order to examine the relationship between the different traits. Results. Most of the studied traits were significantly correlated. A three-component solution explained about 55% of the variation in the observed traits. The first component loaded most strongly on hay fever, serum total IgE, skin test reactivity and sensitisation to grass, cat and house dust mite allergen; the second factor was most associated with asthma, airway obstruction, and airway hyperresponsiveness, whereas the third factor corresponded most strongly to atopic dermatitis. There was some indication of cross-relations between the three components with respect to serum total IgE. Conclusion. Asthma, hay fever, and atopic dermatitis are characterised by different sets of biomarkers suggestive of a high degree of heterogeneity within the atopic syndrome.
AB - Aim. To study the relationship between atopy-related traits in a random sample of children. Methods. A total of 1007 randomly selected children, 7-17 years of age, from Copenhagen, Denmark were studied. The children were interviewed about symptoms of atopic diseases, and skin test reactivity, serum total IgE, lung function, and airway responsiveness were measured. Principal components analysis was performed in order to examine the relationship between the different traits. Results. Most of the studied traits were significantly correlated. A three-component solution explained about 55% of the variation in the observed traits. The first component loaded most strongly on hay fever, serum total IgE, skin test reactivity and sensitisation to grass, cat and house dust mite allergen; the second factor was most associated with asthma, airway obstruction, and airway hyperresponsiveness, whereas the third factor corresponded most strongly to atopic dermatitis. There was some indication of cross-relations between the three components with respect to serum total IgE. Conclusion. Asthma, hay fever, and atopic dermatitis are characterised by different sets of biomarkers suggestive of a high degree of heterogeneity within the atopic syndrome.
U2 - 10.5402/2011/170989
DO - 10.5402/2011/170989
M3 - Journal article
C2 - 23724222
SN - 2090-5521
VL - 2011
SP - 170989
JO - I S R N Allergy
JF - I S R N Allergy
ER -