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Udgivet

Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

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Vis graf over relationer

A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.

OriginalsprogEngelsk
TidsskriftMolecular and Biochemical Parasitology
Vol/bind49
Udgave nummer1
Sider (fra-til)119-31
Antal sider13
ISSN0166-6851
StatusUdgivet - nov. 1991

ID: 46492229