Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Primary Secretory Carcinoma of the Lacrimal Gland: Report of a New Entity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Orbital Lymphoma - An International Multicenter Retrospective Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Natural History of Inherited Retinal Dystrophy due to Biallelic Mutations in the RPE65 Gene

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Lymphoma of the Eyelid - An International Multicenter Retrospective Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Salivary gland carcinomas with unusual presentations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Inverted papilloma of the conjunctiva

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Periocular necrotizing soft tissue infection in Greater Copenhagen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A presentation of culture-positive corneal donors and the effect on clinical outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PURPOSE: Secretory carcinoma has been described in the breast, salivary glands, skin, and other organs, but has not been reported in the lacrimal gland to date. Since lacrimal and salivary glands show similar tumors, we hypothesized that lacrimal secretory carcinoma may exist but has been misclassified in the past.

DESIGN: We undertook a retrospective review of all lacrimal gland tumors at 2 tertiary institutions with centralized ocular pathology practices.

METHODS: A total of 350 lacrimal tumors were reviewed by the authors. Candidate tumors were tested for ETV-NTRK rearrangement by fluorescence in situ hybridization and the presence of the translocation was confirmed by next-generation sequencing.

RESULTS: We identified a single case of secretory carcinoma. The diagnosis was confirmed by demonstrating specific immunohistochemical profile and the presence of ETV6-NTRK3 gene fusion, which is characteristic of secretory carcinoma of other sites. The tumor occurred in a young man who was treated with surgery alone with no recurrence during 12 years of follow-up.

CONCLUSION: Secretory carcinoma is a new lacrimal gland carcinoma type that should be added to the spectrum of low-grade lacrimal gland tumors.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Ophthalmology
Vol/bind193
Sider (fra-til)178-183
Antal sider6
ISSN0002-9394
DOI
StatusUdgivet - sep. 2018

ID: 56468635