Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Primary malignant melanoma of the urethra in a patient with rheumatoid arthritis treated with methotrexate

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Severe hypophosphataemia following oral bisphosphonate treatment in a patient with osteoporosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Intracranial entrapment of a haemodialysis catheter guidewire

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Rare cause of spontaneous haemothorax: mediastinal and distant lymph node metastases from uveal melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Acquired complement C1 esterase inhibitor deficiency in a patient with a rare SERPING1 variant with unknown significance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Germ cells positive for PLAP and c-Kit in 11-16 year old normal boys with ongoing spermatogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Richter's transformation in patients with chronic lymphocytic leukaemia: a Nationwide Epidemiological Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Postnatal germ cell development in cryptorchid boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

We report a case of a 79-year-old woman with urinary incontinence who presented at a urogynaecology appointment. Her medical history included rheumatoid arthritis (RA) treated with methotrexate (MXT) for 22 years. A polypoidal lesion was protruding from the meatus urethrae. The histoimmunocytology confirmed a primary superficial spreading malignant melanoma. The tumour was extensively excised, but 8 months later, due to a lymphatic nodal swelling, a positron emission tomography/CT was performed showing a process suspicious of malignant melanoma and multiple distant metastasis. The subsequent treatment was palliative and 1 year later, the patient died. The aetiology of malignant melanomas in the urethra is poorly understood. There is consistent evidence that RA is associated with a number of cancers, but it remains controversial whether this risk is increased with MXT. This case emphasises the importance of gynaecological examination even in patients with only weak symptoms from the pelvic region, especially in patients undergoing immunosuppressive treatment.

OriginalsprogEngelsk
Artikelnummere228033
TidsskriftBMJ Case Reports
Vol/bind12
Udgave nummer4
Antal sider3
ISSN1757-790X
DOI
StatusUdgivet - 2019

Bibliografisk note

© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 57215715