@article{981ec0d234e24ae097dc548c25223a49,
title = "PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53",
abstract = "Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis, necessitating the need to develop new and efficient treatment modalities. PRIMA-1(Met) (p53-dependent reactivation of massive apoptosis), also known as APR-246, is a small molecule, which restores tumor suppressor function to mutant p53 and induces cancer cell death in various cancer types. Since p53 is mutated in more than 90% of SCLC, we investigated the ability of PRIMA-1(Met) to induce apoptosis and inhibit tumor growth in SCLC with different p53 mutations.",
keywords = "Animals, Antineoplastic Agents, Apoptosis, Cell Line, Tumor, Cell Proliferation, Disease Progression, Genes, p53, Humans, Lung Neoplasms, Male, Mice, Mice, Nude, Mutant Proteins, Quinuclidines, Small Cell Lung Carcinoma, Time Factors, Xenograft Model Antitumor Assays",
author = "Roza Zandi and Galina Selivanova and Christensen, {Camilla Laulund} and Gerds, {Thomas Alexander} and Willumsen, {Berthe Marie} and Poulsen, {Hans Skovgaard}",
note = "{\textcopyright}2011 AACR.",
year = "2011",
month = may,
day = "1",
doi = "10.1158/1078-0432.CCR-10-3168",
language = "English",
volume = "17",
pages = "2830--41",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research (A A C R)",
number = "9",
}