Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6

Lu Li; Masahiro Itoh; Maila Ablake; Battesimo Macrì; Klaus Bendtzen; Ferdinando Nicoletti

doi:10.1006/clim.2001.5155

Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6

Lu Li, Masahiro Itoh, Maila Ablake, Battesimo Macrì, Klaus Bendtzen, Ferdinando Nicoletti

16 Citationer (Scopus)

Abstract

We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.

Originalsprog	Engelsk
Tidsskrift	Clinical Immunology
Vol/bind	102
Udgave nummer	2
Sider (fra-til)	135-7
Antal sider	3
ISSN	1521-6616
DOI	https://doi.org/10.1006/clim.2001.5155
Status	Udgivet - 1 feb. 2002
Udgivet eksternt	Ja

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10.1006/clim.2001.5155

Citationsformater

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title = "Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6",

abstract = "We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.",

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AU - Li, Lu

AU - Itoh, Masahiro

AU - Ablake, Maila

AU - Macrì, Battesimo

AU - Bendtzen, Klaus

AU - Nicoletti, Ferdinando

PY - 2002/2/1

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AB - We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.

U2 - 10.1006/clim.2001.5155

DO - 10.1006/clim.2001.5155

M3 - Journal article

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SN - 1521-6616

VL - 102

SP - 135

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JO - Clinical Immunology

JF - Clinical Immunology

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Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6

Abstract

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