Prevention of diabetes in NOD mice by repeated exposures to a contact allergen inducing a sub-clinical dermatitis

Kaare Engkilde, Karsten Buschard, Axel Jacob Kornerup Hansen, Torkil Menné, Jeanne Duus Johansen

11 Citationer (Scopus)

Abstract

Type 1 diabetes is an autoimmune disease, while allergic contact dermatitis although immune mediated, is considered an exposure driven disease that develops due to epicutaneous contact with reactive low-molecular chemicals. The objective of the present study was to experimentally study the effect of contact allergens on the development of diabetes in NOD mice. As the link between contact allergy and diabetes is yet unexplained we also examined the effect of provocation with allergens on Natural Killer T (NKT) cells, since involvement of NKT cells could suggest an innate connection between the two diseases.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind5
Udgave nummer5
Sider (fra-til)e10591
ISSN1932-6203
DOI
StatusUdgivet - 1 jan. 2010

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