Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Prevention of depression in patients with acute coronary syndrome (DECARD) randomized trial: effects on and by self-reported health

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Concordance of child self-reported psychotic experiences with interview- and observer-based psychotic experiences

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Development of a fidelity scale for Danish specialized early interventions service

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Sex differences in trauma exposure and symptomatology in trauma-affected refugees

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effectiveness of cognitive remediation in the ultra-high risk state for psychosis

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

Vis graf over relationer

AIM: Escitalopram may prevent depression following acute coronary syndrome. We sought to estimate the effects of escitalopram on self-reported health and to identify subgroups with higher efficacy.

METHODS: This is a secondary analysis of a 12-month double-blind clinical trial randomizing non-depressed acute coronary syndrome patients to escitalopram (n = 120) or matching placebo (n = 120). The main outcomes were mean scores on Short Form 36 Health Survey (SF-36) domains, and diagnosis of depression was adjusted for baseline SF-36 scores.

RESULTS: Escitalopram did not yield different SF-36 trajectories on any scale compared with placebo (P > 0.28). Efficacy of escitalopram may have been better among those scoring at least the normative score on general health perceptions (hazard ratio (HR) for depression 0.17 (95% confidence interval 0.02-1.42) ) or social functioning (HR = 0.12 (0.02-0.99) ) than in the full sample of patients (HR = 0.20 (0.04-0.90) ), although not statistically significant.

CONCLUSIONS: The SF-36 may be too broad an outcome measure in trials or treatments that seek to prevent depression following acute coronary syndrome. The SF-36 may, however, indicate who is more likely to benefit from treatment.

OriginalsprogEngelsk
TidsskriftEarly Intervention in Psychiatry
Vol/bind9
Udgave nummer5
Sider (fra-til)370-7
Antal sider8
ISSN1751-7885
DOI
StatusUdgivet - okt. 2015

ID: 45824836