Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Rosanna Di Paola; Roberto Di Marco; Emanuela Mazzon; Tiziana Genovese; Klaus Bendtzen; Battesimo Macrì; Ferdinando Nicoletti; Salvatore Cuzzocrea

doi:10.1016/j.clim.2004.05.008

Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Rosanna Di Paola, Roberto Di Marco, Emanuela Mazzon, Tiziana Genovese, Klaus Bendtzen, Battesimo Macrì, Ferdinando Nicoletti, Salvatore Cuzzocrea

12 Citationer (Scopus)

Abstract

CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.

Originalsprog	Engelsk
Tidsskrift	Clinical Immunology
Vol/bind	113
Udgave nummer	1
Sider (fra-til)	64-73
Antal sider	10
ISSN	1521-6616
DOI	https://doi.org/10.1016/j.clim.2004.05.008
Status	Udgivet - 1 okt. 2004

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10.1016/j.clim.2004.05.008

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title = "Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody",

abstract = "CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.",

author = "{Di Paola}, Rosanna and {Di Marco}, Roberto and Emanuela Mazzon and Tiziana Genovese and Klaus Bendtzen and Battesimo Macr{\`i} and Ferdinando Nicoletti and Salvatore Cuzzocrea",

year = "2004",

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doi = "10.1016/j.clim.2004.05.008",

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T1 - Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

AU - Di Paola, Rosanna

AU - Di Marco, Roberto

AU - Mazzon, Emanuela

AU - Genovese, Tiziana

AU - Bendtzen, Klaus

AU - Macrì, Battesimo

AU - Nicoletti, Ferdinando

AU - Cuzzocrea, Salvatore

PY - 2004/10/1

Y1 - 2004/10/1

N2 - CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.

AB - CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.

U2 - 10.1016/j.clim.2004.05.008

DO - 10.1016/j.clim.2004.05.008

M3 - Journal article

C2 - 15380531

SN - 1521-6616

VL - 113

SP - 64

EP - 73

JO - Clinical Immunology

JF - Clinical Immunology

IS - 1

ER -

Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Abstract

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