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Prevalence of rheumatic heart disease in adults from the Brazilian Amazon Basin

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Left atrial contractile strain predicts recurrence of atrial tachyarrhythmia after catheter ablation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Global and regional wall motion abnormalities and incident heart failure in the general population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Left atrial contractile strain predicts recurrence of atrial tachyarrhythmia after catheter ablation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Global and regional wall motion abnormalities and incident heart failure in the general population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The metabolic signature of cardiovascular disease and arterial calcification in patients with chronic kidney disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Background: Rheumatic heart disease (RHD) continues to be a burden in low- and middle-income countries and prevalence estimates are lacking from South America. We aimed to determine the prevalence of RHD in the Brazilian Amazon Basin. Methods: We examined a random sample of adults (≥18 years) from the general population, who underwent echocardiographic image acquisition by a medical doctor. All images were analyzed according to (i) the 2012 World Heart Federation criteria and (ii) a simplified algorithm for RHD from a previously validated risk score (categories: low-, medium-, high-risk) which involved assessment of the mitral valve (leaflet thickening and excessive motion, regurgitation jet length) and aortic valve (thickening and any regurgitation). Results: A total of 488 adults were screened (mean age 40 ± 15 years, 38% men). The prevalence of RHD was 39/1000 adults (n = 17 definite and n = 2 borderline). Fourteen (74%) had pathological mitral regurgitation, four (21%) mitral stenosis, 0 (0%) pathological aortic regurgitation and six (32%) both mitral and aortic valve disease. None had a prior diagnosis of RHD, 10 (53%) had positive cardiac auscultation and two (11%) reported a history of rheumatic fever. The simplified algorithm identified four (21%) adults as low-risk, six (32%) as intermediate, and nine (47%) as high-risk. Conclusions: The prevalence of RHD was 39/1000 in adults from the Brazilian Amazon Basin, indicating the need for screening programs in remote areas. A simplified model was only able to categorize every second case of RHD as high-risk. External validation of simplified screening models to increase feasibility in clinical practice are encouraged.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cardiology
Vol/bind352
Sider (fra-til)115-122
Antal sider8
ISSN0167-5273
DOI
StatusUdgivet - 1 apr. 2022

Bibliografisk note

Funding Information:
PB and AEH: Jette and Hans Henrik Jensen , The Independent Research Fund Denmark ( 0129-0003B ), Dansk Medicinsk Selskab København ( 120620-kms ), Julie von Müllens Fond , Knud Højgaards Fond ( 18-05-2487 ), A. P. Møllers Lægefond ( 18-L-0026 ), Reinholdt W. Jorck og Hustrus Fond ( 18-JU-0485 ), Eva og Henry Frænkels Mindefond ( NLA-080919 ), Astra Zeneca/Danish Society of Cardiology , Internal Funds at Herlev-Gentofte Hospital , Torben og Alice Frimodts Fond ( TA250419 ), Brorsons Fond ( 12038-1-hh ), Lundbeck Foundation ( R373-2021-1201 ). AW: Danish Heart Association ( 20-R139-A9644-22165 ), William Demant ( 20-1257 ), Knud Højgaards Fond ( 20-01-1076 ), Reinholdt W. Jorck og Hustrus Fond ( 20-JU-0145 ). MK: Novo Nordisk Fonden ( NNF20OC0062782 ). LCG: CNPq ( 142306/2020-7 ).

Funding Information:
PB and AEH: Jette and Hans Henrik Jensen, The Independent Research Fund Denmark (0129-0003B), Dansk Medicinsk Selskab K?benhavn (120620-kms), Julie von M?llens Fond, Knud H?jgaards Fond (18-05-2487), A. P. M?llers L?gefond (18-L-0026), Reinholdt W. Jorck og Hustrus Fond (18-JU-0485), Eva og Henry Fr?nkels Mindefond (NLA-080919), Astra Zeneca/Danish Society of Cardiology, Internal Funds at Herlev-Gentofte Hospital, Torben og Alice Frimodts Fond (TA250419), Brorsons Fond (12038-1-hh), Lundbeck Foundation (R373-2021-1201). AW: Danish Heart Association (20-R139-A9644-22165), William Demant (20-1257), Knud H?jgaards Fond (20-01-1076), Reinholdt W. Jorck og Hustrus Fond (20-JU-0145). MK: Novo Nordisk Fonden (NNF20OC0062782). LCG: CNPq (142306/2020-7).CRFM: FAPESP (2020/06747-4) and CNPq (302917/2019-5).

Publisher Copyright:
© 2022 Elsevier B.V.

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