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Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta-analysis

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Harvard

de la Cour, CD, Sperling, CD, Belmonte, F, Syrjänen, S, Verdoodt, F & Kjaer, SK 2020, 'Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta-analysis', Head and Neck, bind 42, nr. 10, s. 2975-2984. https://doi.org/10.1002/hed.26330

APA

de la Cour, C. D., Sperling, C. D., Belmonte, F., Syrjänen, S., Verdoodt, F., & Kjaer, S. K. (2020). Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta-analysis. Head and Neck, 42(10), 2975-2984. https://doi.org/10.1002/hed.26330

CBE

MLA

Vancouver

Author

de la Cour, Cecilie Dovey ; Sperling, Cecilie Dyg ; Belmonte, Federica ; Syrjänen, Stina ; Verdoodt, Freija ; Kjaer, Susanne Krüger. / Prevalence of human papillomavirus in oral epithelial dysplasia : Systematic review and meta-analysis. I: Head and Neck. 2020 ; Bind 42, Nr. 10. s. 2975-2984.

Bibtex

@article{fbf23f424f6148a68ba6a5507dccf226,
title = "Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta-analysis",
abstract = "The purpose of this systematic review and meta-analysis was to estimate the overall and type-specific prevalence of human papillomavirus (HPV) DNA in oral epithelial dysplasia and assess p16INK4a overexpression in relation to HPV-status. A systematic literature search identified 31 eligible studies (832 cases) evaluating the presence of HPV DNA in oral epithelial dysplasia cases by PCR. Of these, six studies evaluated p16INK4a overexpression in relation to HPV-status. The overall pooled prevalence of HPV DNA in oral epithelial dysplasia was 27.2% (95% CI: 17.6-38.1). We observed substantial interstudy heterogeneity, which could not be explained by differences in continent, tissue type, or severity of epithelial dysplasia. HPV16 was the predominant genotype detected. Moreover, 62.2% of HPV positive and 17.8% of HPV negative oral epithelial dysplasia samples stained intensively positive for p16INK4a . This meta-analysis found that 27% of oral epithelial dysplasia harbor HPV DNA. Whether this represents a transient infection or has a carcinogenic role is unknown.",
keywords = "human papillomavirus, meta-analysis, oral dysplasia, p16, prevalence",
author = "{de la Cour}, {Cecilie Dovey} and Sperling, {Cecilie Dyg} and Federica Belmonte and Stina Syrj{\"a}nen and Freija Verdoodt and Kjaer, {Susanne Kr{\"u}ger}",
note = "{\textcopyright} 2020 Wiley Periodicals, Inc.",
year = "2020",
month = oct,
doi = "10.1002/hed.26330",
language = "English",
volume = "42",
pages = "2975--2984",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "10",

}

RIS

TY - JOUR

T1 - Prevalence of human papillomavirus in oral epithelial dysplasia

T2 - Systematic review and meta-analysis

AU - de la Cour, Cecilie Dovey

AU - Sperling, Cecilie Dyg

AU - Belmonte, Federica

AU - Syrjänen, Stina

AU - Verdoodt, Freija

AU - Kjaer, Susanne Krüger

N1 - © 2020 Wiley Periodicals, Inc.

PY - 2020/10

Y1 - 2020/10

N2 - The purpose of this systematic review and meta-analysis was to estimate the overall and type-specific prevalence of human papillomavirus (HPV) DNA in oral epithelial dysplasia and assess p16INK4a overexpression in relation to HPV-status. A systematic literature search identified 31 eligible studies (832 cases) evaluating the presence of HPV DNA in oral epithelial dysplasia cases by PCR. Of these, six studies evaluated p16INK4a overexpression in relation to HPV-status. The overall pooled prevalence of HPV DNA in oral epithelial dysplasia was 27.2% (95% CI: 17.6-38.1). We observed substantial interstudy heterogeneity, which could not be explained by differences in continent, tissue type, or severity of epithelial dysplasia. HPV16 was the predominant genotype detected. Moreover, 62.2% of HPV positive and 17.8% of HPV negative oral epithelial dysplasia samples stained intensively positive for p16INK4a . This meta-analysis found that 27% of oral epithelial dysplasia harbor HPV DNA. Whether this represents a transient infection or has a carcinogenic role is unknown.

AB - The purpose of this systematic review and meta-analysis was to estimate the overall and type-specific prevalence of human papillomavirus (HPV) DNA in oral epithelial dysplasia and assess p16INK4a overexpression in relation to HPV-status. A systematic literature search identified 31 eligible studies (832 cases) evaluating the presence of HPV DNA in oral epithelial dysplasia cases by PCR. Of these, six studies evaluated p16INK4a overexpression in relation to HPV-status. The overall pooled prevalence of HPV DNA in oral epithelial dysplasia was 27.2% (95% CI: 17.6-38.1). We observed substantial interstudy heterogeneity, which could not be explained by differences in continent, tissue type, or severity of epithelial dysplasia. HPV16 was the predominant genotype detected. Moreover, 62.2% of HPV positive and 17.8% of HPV negative oral epithelial dysplasia samples stained intensively positive for p16INK4a . This meta-analysis found that 27% of oral epithelial dysplasia harbor HPV DNA. Whether this represents a transient infection or has a carcinogenic role is unknown.

KW - human papillomavirus

KW - meta-analysis

KW - oral dysplasia

KW - p16

KW - prevalence

UR - http://www.scopus.com/inward/record.url?scp=85087176223&partnerID=8YFLogxK

U2 - 10.1002/hed.26330

DO - 10.1002/hed.26330

M3 - Review

C2 - 32573035

VL - 42

SP - 2975

EP - 2984

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 10

ER -

ID: 61556166