Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

Nanna Ravnborg; Danni Ambikaibalan; Gaurav Agnihotri; Shmuel Price; Supriya Rastogi; Kevin R Patel; Vivek Singam; Yuki Andersen; Anne-Sofie Halling; Jonathan I Silverberg; Alexander Egeberg; Jacob P Thyssen

doi:10.1016/j.jaad.2020.02.055

Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

Nanna Ravnborg, Danni Ambikaibalan, Gaurav Agnihotri, Shmuel Price, Supriya Rastogi, Kevin R Patel, Vivek Singam, Yuki Andersen, Anne-Sofie Halling, Jonathan I Silverberg, Alexander Egeberg, Jacob P Thyssen

51 Citationer (Scopus)

Abstract

BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).

OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.

METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.

RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).

LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.

CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

Originalsprog	Engelsk
Tidsskrift	Journal of the American Academy of Dermatology
Vol/bind	84
Udgave nummer	2
Sider (fra-til)	471-478
Antal sider	8
ISSN	0190-9622
DOI	https://doi.org/10.1016/j.jaad.2020.02.055
Status	Udgivet - feb. 2021

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Ravnborg, N., Ambikaibalan, D., Agnihotri, G., Price, S., Rastogi, S., Patel, K. R., Singam, V., Andersen, Y., Halling, A.-S., Silverberg, J. I., Egeberg, A., & Thyssen, J. P. (2021). Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis. Journal of the American Academy of Dermatology, 84(2), 471-478. https://doi.org/10.1016/j.jaad.2020.02.055

Ravnborg, N, Ambikaibalan, D, Agnihotri, G, Price, S, Rastogi, S, Patel, KR, Singam, V, Andersen, Y, Halling, A-S, Silverberg, JI, Egeberg, A & Thyssen, JP 2021, 'Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis', Journal of the American Academy of Dermatology, bind 84, nr. 2, s. 471-478. https://doi.org/10.1016/j.jaad.2020.02.055

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abstract = "BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.",

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author = "Nanna Ravnborg and Danni Ambikaibalan and Gaurav Agnihotri and Shmuel Price and Supriya Rastogi and Patel, {Kevin R} and Vivek Singam and Yuki Andersen and Anne-Sofie Halling and Silverberg, {Jonathan I} and Alexander Egeberg and Thyssen, {Jacob P}",

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AU - Ravnborg, Nanna

AU - Ambikaibalan, Danni

AU - Agnihotri, Gaurav

AU - Price, Shmuel

AU - Rastogi, Supriya

AU - Patel, Kevin R

AU - Singam, Vivek

AU - Andersen, Yuki

AU - Halling, Anne-Sofie

AU - Silverberg, Jonathan I

AU - Egeberg, Alexander

AU - Thyssen, Jacob P

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N2 - BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

AB - BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

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Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

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