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Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

Publikation: Bidrag til tidsskriftReviewpeer review


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BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).

OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.

METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.

RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).

LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.

CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

TidsskriftJournal of the American Academy of Dermatology
Udgave nummer2
Sider (fra-til)471-478
Antal sider8
StatusUdgivet - feb. 2021

Bibliografisk note

Copyright © 2020 American Academy of Dermatology, Inc. All rights reserved.

ID: 61783763