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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Prevalence of anti-Hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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BACKGROUND: Hepatitis E virus (HEV) genotype-3 is endemic in Europe and the infection is mostly subclinical or acute self-limiting. However, persistent infection is described among HIV-infected individuals. The prevalence of antibodies against HEV (anti-HEV) among HIV-infected persons varies geographically and is unknown in Denmark. We investigated rates of co-infection with HEV among HIV-infected individuals in Denmark over three decades from the early 1980s to 2013.

STUDY DESIGN AND METHODS: A total of 2506 HIV-infected persons were investigated from two cohorts followed at Hvidovre Hospital, Denmark. Blood samples were retrospectively tested for anti-HEV from 2216 persons who were included in a prospective clinical cohort and followed between 1995 until 2013, as well as from 290 persons from a historical cohort followed between 1980-1994. Serial samples were tested for HEV RNA for anti-HEV seroconverting individuals. Factors associated with anti-HEV status were explored using multivariable logistic regression analysis.

RESULTS: The overall HEV seroprevalence rates were stable during the 1980s, the 1990s and 2000-2013 (23.1 %, 22.9% and 23.7%, respectively). In all decades, rates of anti-HEV increased with older age, and anti-HEV seropositivity were associated with older generations, HIV risk group and geographic origin. Persistent HEV infection was not detected in any of 57 individuals with anti-HEV seroconversion.

CONCLUSION: HEV seroprevalence rates were stable in HIV-infected individuals from the early 1980s to 2013. Rates increased with age. No evidence of persistent HEV infection was detected. Infection with HEV is frequent, but persistent HEV infection is rare among HIV-infected individuals.

OriginalsprogEngelsk
TidsskriftInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN1201-9712
DOI
StatusE-pub ahead of print - 4 maj 2019

Bibliografisk note

Copyright © 2019. Published by Elsevier Ltd.

ID: 57103291