TY - JOUR
T1 - Prevalence and outcomes of pregnancies in women with HIV over a 20-year period
T2 - The EuroSIDA study, 1996 to 2015
AU - Kowalska, Justyna D
AU - Pelchen-Matthews, Annegret
AU - Ryom, Lene
AU - Losso, Marcelo H
AU - Trofimova, Tatiana
AU - Mitsura, Viktar M
AU - Khromova, Irina
AU - Paduta, Dzmitry
AU - Stephan, Christoph
AU - Domingo, Pere
AU - Bakowska, Elzbieta
AU - Monforte, Antonella d'Arminio
AU - Oestergaard, Lars
AU - Jablonowska, Elzbieta
AU - Kuznetsova, Anastasiia
AU - Moreno, Santiago
AU - Vasylyev, Marta
AU - Pradier, Christian
AU - Battegay, Manuel
AU - Vandekerckhove, Linos
AU - Castagna, Antonella
AU - Raben, Dorthe
AU - Mocroft, Amanda
AU - EuroSIDA study group
N1 - Copyright © 2021 Wolters Kluwer Health, Inc.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - OBJECTIVE: To evaluate time trends in pregnancies and pregnancy outcomes among women with HIV in Europe.DESIGN: European multicentre prospective cohort study.METHODS: EuroSIDA has collected annual cross-sectional audits of pregnancies between 1996 and 2015. Pregnancy data were extracted and described. Odds of pregnancy were modelled, adjusting for potential confounders using logistic regression with generalized estimating equations.RESULTS: Of 5535 women aged 16 to <50 years, 4217 (76.2%) had pregnancy information available, and 912 (21.6%) reported 1315 pregnancies. The proportions with at least one pregnancy were 28.1% (321/1143) in East, 24.5% (146/596) in North, 19.8% (140/706) in West/Central, 19.3% (110/569) in Central East and 16.2% (195/1203) in South Europe. Overall 319 pregnancies (24.3%) occurred in 1996-2002, 576 (43.8%) in 2003-2009 and 420 (31.9%) in 2010-2015. After adjustment, the odds of pregnancy were lower in 1996-2002, in South, Central East and East compared to West/Central Europe, in older women, those with low CD4+ cell count or with prior AIDS, and higher in those with a previous pregnancy or who were hepatitis C virus positive.Outcomes were reported for 999 pregnancies in 1996-2014, with 690 live births (69.1%), seven stillbirths (0.7%), 103 spontaneous (10.3%) and 199 medical abortions (19.9%).CONCLUSIONS: Around 20% of women in EuroSIDA reported a pregnancy, with most pregnancies after 2002, when more effective antiretroviral therapy became available. Substantial differences were seen between European regions. Further surveillance of pregnancies and outcomes among women living with HIV is warranted to ensure equal access to care.
AB - OBJECTIVE: To evaluate time trends in pregnancies and pregnancy outcomes among women with HIV in Europe.DESIGN: European multicentre prospective cohort study.METHODS: EuroSIDA has collected annual cross-sectional audits of pregnancies between 1996 and 2015. Pregnancy data were extracted and described. Odds of pregnancy were modelled, adjusting for potential confounders using logistic regression with generalized estimating equations.RESULTS: Of 5535 women aged 16 to <50 years, 4217 (76.2%) had pregnancy information available, and 912 (21.6%) reported 1315 pregnancies. The proportions with at least one pregnancy were 28.1% (321/1143) in East, 24.5% (146/596) in North, 19.8% (140/706) in West/Central, 19.3% (110/569) in Central East and 16.2% (195/1203) in South Europe. Overall 319 pregnancies (24.3%) occurred in 1996-2002, 576 (43.8%) in 2003-2009 and 420 (31.9%) in 2010-2015. After adjustment, the odds of pregnancy were lower in 1996-2002, in South, Central East and East compared to West/Central Europe, in older women, those with low CD4+ cell count or with prior AIDS, and higher in those with a previous pregnancy or who were hepatitis C virus positive.Outcomes were reported for 999 pregnancies in 1996-2014, with 690 live births (69.1%), seven stillbirths (0.7%), 103 spontaneous (10.3%) and 199 medical abortions (19.9%).CONCLUSIONS: Around 20% of women in EuroSIDA reported a pregnancy, with most pregnancies after 2002, when more effective antiretroviral therapy became available. Substantial differences were seen between European regions. Further surveillance of pregnancies and outcomes among women living with HIV is warranted to ensure equal access to care.
KW - Abortion, Induced
KW - Aged
KW - Cross-Sectional Studies
KW - Female
KW - HIV Infections/epidemiology
KW - Humans
KW - Pregnancy
KW - Prevalence
KW - Prospective Studies
UR - http://www.scopus.com/inward/record.url?scp=85115443848&partnerID=8YFLogxK
U2 - 10.1097/QAD.0000000000002954
DO - 10.1097/QAD.0000000000002954
M3 - Journal article
C2 - 34033590
SN - 0269-9370
VL - 35
SP - 2025
EP - 2033
JO - AIDS
JF - AIDS
IS - 12
ER -