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Prevalence and diagnostic outcomes of children with duodenal lesions and negative celiac serology

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  • Ida Gustafsson
  • Marleena Repo
  • Alina Popp
  • Katri Kaukinen
  • Pauliina Hiltunen
  • Taina Arvola
  • Juha Taavela
  • Martine Vornanen
  • Laura Kivelä
  • Kalle Kurppa
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BACKGROUND: Celiac disease diagnostics begin by measuring autoantibodies, which may fail to identify seronegative patients. Duodenal lesion in the absence of antibodies is scarcely studied, especially in children.

AIMS: To investigate the prevalence and diagnostic outcomes of children with seronegative duodenal lesion in two countries with different disease profiles.

METHODS: Medical data, including the results of histology and transglutaminase (tTGab) and endomysium (EmA) antibody measurements were collected from 1172 Finnish and 264 Romanian children with systematic duodenal sampling. Database of 509 Finnish children with celiac disease was examined to identify earlier seronegative patients.

RESULTS: Celiac disease was diagnosed in 307 Finnish and 83 Romanian children in the endoscopy cohorts. No seronegative patients were found among 899 celiac disease patients, although some were only tTGab or EmA positive. Non-celiac duodenal lesion was detected in eight Finnish and 32 Romanian children, their most common diagnoses being inflammatory bowel disease and infections, respectively. Six children with morphological lesion received no diagnosis. None of them developed celiac disease during a follow-up of 3-11 years.

CONCLUSION: Pediatric seronegative celiac disease is exceptional in the era of modern autoantibodies. Other reasons for duodenal lesion should therefore be sought, bearing in mind possible differences across countries.

OriginalsprogEngelsk
TidsskriftDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Vol/bind52
Udgave nummer3
Sider (fra-til)289-295
Antal sider7
ISSN1590-8658
DOI
StatusUdgivet - mar. 2020

Bibliografisk note

Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

ID: 61766068