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Pretreatment with 5-Fluorouracil Cream Enhances the Efficacy of Daylight-mediated Photodynamic Therapy for Actinic Keratosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Daylight PDT acts by continuous activation of PpIX

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Serum 25(OH)D levels after oral vitamin D3 supplementation and UVB exposure correlate

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone. At 3-month follow-up the overall lesion response rate was significantly higher for the combination of 5-FU and daylight-PDT (62.7%) than for daylight-PDT alone (51.8%) (p = 0.001). Furthermore, pain and erythema in relation to treatment were similar in the 2 groups (p = 1.0 and p = 0.2, respectively). Combination therapy is a safe and effective method to improve daylight-PDT for acral AKs.

TidsskriftActa Dermato-Venereologica
Udgave nummer5
Sider (fra-til)617-621
Antal sider5
StatusUdgivet - 8 maj 2017

ID: 52376727