Preterm birth and cerebral palsy. Predictive value of pregnancy complications, mode of delivery, and Apgar scores.

Bidragets oversatte titel: Preterm birth and cerebral palsy. Predictive value of pregnancy complications, mode of delivery, and Apgar scores.

Monica Wedell Topp, J Langhoff-Roos, P Uldall

29 Citationer (Scopus)

Abstrakt

BACKGROUND: Preterm infants are at 8 times higher risk than term infants for pre- and perinatal brain damage, resulting in cerebral palsy. In this paper we have analysed the influence of prenatal and birth-related risk factors on cerebral palsy in preterm infants. METHODS: In a register-based study, 175 preterm singleton infants with cerebral palsy, born in 1982-86, were compared with 687 controls matched by gestational age and year of birth. RESULTS: Statistically significant higher rates in cases were found in parity > or = 3 (22% vs. 16%, p < 0.05), Cesarean section (67% vs. 56%, p < 0.01), and low Apgar scores at 1 minute (45% vs. 36%, p < 0.05). By multivariate analyses, two variables remained statistically significant: parity > or = 3 (adjusted OR = 1.53 (95% CI 1.00-2.34), p < 0.05) and Cesarean section (adjusted OR = 1.57 (95% CI 1.07-2.32), p < 0.05). CONCLUSIONS: Pregnancy complications preceding preterm birth did not imply a higher risk of cerebral palsy. Delivery by Cesarean section was a prognostic factor for developing cerebral palsy, and the predictive value of Apgar scores was highly limited.
Bidragets oversatte titelPreterm birth and cerebral palsy. Predictive value of pregnancy complications, mode of delivery, and Apgar scores.
OriginalsprogEngelsk
TidsskriftActa Obstetricia et Gynecologica Scandinavica
Vol/bind76
Udgave nummer9
Sider (fra-til)843-848
Antal sider6
ISSN0001-6349
StatusUdgivet - 1997

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