Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Preoperative predictors of inguinal lymph node metastases in vulvar cancer - A nationwide study

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  1. Prognostic value of the 2018 FIGO staging system for cervical cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Assessment of recurrence rate and risk factors of relapse in stage in IA vulvar carcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. miRNA Expression in Ovarian Cancer in Fresh Frozen, Formalin-fixed Paraffin-embedded and Plasma Samples

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Prognostic value of the 2018 FIGO staging system for cervical cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. The value of next-generation sequencing in routine diagnostics and management of patients with cytopenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

BACKGROUND: A combination of tumour size, differentiation grade and location may identify a group of vulvar squamous cell cancer (VSCC) patients with a very low risk of inguinal lymph node metastasis. We aim to examine these findings in a large national cohort of VSCC patients.

MATERIALS AND METHODS: Population based prospective data on VSCC patients treated with vulvectomy and primary groin surgery was obtained from the Danish Gynaecological Cancer Database. Univariate chi-square and multivariate logistic regression analysis were used. Statistical tests were 2-sided. P-values of <0.05 were considered statistically significant.

RESULTS: In all, 388 VSCC patients were identified. Of these 264 (63.3%) were node negative and 121 (36.7%) node positive. Increasing tumour size (diameter ≤ 2 cm vs. > 2 to 4 cm), grade (1 vs. 2-3) and location of tumour to clitoris were all associated with a significantly increased risk of inguinal lymph node metastasis OR 2.81(95% CI 1.52-5.20), OR 3.19 (95% CI 1.77-5.74) and OR 2.74 (95% CI 1.56-5.20), respectively. Previous vulvar disease was not associated with lymph node metastasis. No lymph node metastasis was demonstrated in patients with grade 1 tumours, tumour size less than 2 cm and located outside the clitoris area (n = 51).

CONCLUSIONS: VSCC patients with grade 1 tumours, ≤ 2 cm and without clitoral involvement have a very low risk of inguinal lymph node metastasis. These patients may be spared inguinal lymph node staging to decrease operating time and peri- and postoperative morbidity in the future. However, studies validating our findings are needed.

OriginalsprogEngelsk
TidsskriftGynecologic Oncology
Vol/bind165
Udgave nummer3
Sider (fra-til)420-427
Antal sider8
ISSN0090-8258
DOI
StatusUdgivet - jun. 2022

Bibliografisk note

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

ID: 77842800