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Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age

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@article{49fbeb20358d4f65b677329e837a6ccf,
title = "Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age",
abstract = "BACKGROUND: Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.METHODS: In a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).RESULTS: There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75{\%}). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95{\%} CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 {\%} of predicted value < 90{\%}).CONCLUSION AND CLINICAL RELEVANCE: Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.",
keywords = "Chromatography, Gas, Dichlorodiphenyl Dichloroethylene, Environmental Exposure, Environmental Pollutants, Female, Follow-Up Studies, Hexachlorobenzene, Humans, Hypersensitivity, Male, Mass Spectrometry, Maternal Exposure, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects, Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "S Hansen and M Str{\o}m and Olsen, {S F} and R Dahl and Hoffmann, {H J} and Charlotta Granstr{\"o}m and Dorte Rytter and Bech, {B H} and A Linneberg and Ekaterina Maslova and H Kiviranta and Panu Rantakokko and Halldorsson, {T I}",
note = "{\circledC} 2015 John Wiley & Sons Ltd.",
year = "2016",
month = "2",
doi = "10.1111/cea.12631",
language = "English",
volume = "46",
pages = "329--36",
journal = "Clinical Allergy",
issn = "0954-7894",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age

AU - Hansen, S

AU - Strøm, M

AU - Olsen, S F

AU - Dahl, R

AU - Hoffmann, H J

AU - Granström, Charlotta

AU - Rytter, Dorte

AU - Bech, B H

AU - Linneberg, A

AU - Maslova, Ekaterina

AU - Kiviranta, H

AU - Rantakokko, Panu

AU - Halldorsson, T I

N1 - © 2015 John Wiley & Sons Ltd.

PY - 2016/2

Y1 - 2016/2

N2 - BACKGROUND: Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.METHODS: In a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).RESULTS: There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%).CONCLUSION AND CLINICAL RELEVANCE: Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.

AB - BACKGROUND: Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.METHODS: In a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).RESULTS: There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%).CONCLUSION AND CLINICAL RELEVANCE: Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.

KW - Chromatography, Gas

KW - Dichlorodiphenyl Dichloroethylene

KW - Environmental Exposure

KW - Environmental Pollutants

KW - Female

KW - Follow-Up Studies

KW - Hexachlorobenzene

KW - Humans

KW - Hypersensitivity

KW - Male

KW - Mass Spectrometry

KW - Maternal Exposure

KW - Polychlorinated Biphenyls

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Pulmonary Disease, Chronic Obstructive

KW - Respiratory Function Tests

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/cea.12631

DO - 10.1111/cea.12631

M3 - Journal article

VL - 46

SP - 329

EP - 336

JO - Clinical Allergy

JF - Clinical Allergy

SN - 0954-7894

IS - 2

ER -

ID: 50012945