Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Prenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Bronchoscopic mucosal cryobiopsies as a method for studying airway disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Advancing the management of Obstructive Airways Diseases through Translational Research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Determinants of low risk of asthma exacerbation during pregnancy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. High breast milk IL-1β level is associated with reduced risk of childhood eczema

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Predictors of accelerated FEV1 decline in adults with airflow limitation-Findings from the Health2006 cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Prenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.

METHODS: In a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).

RESULTS: There were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%).

CONCLUSION AND CLINICAL RELEVANCE: Our data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.

OriginalsprogEngelsk
TidsskriftClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Vol/bind46
Udgave nummer2
Sider (fra-til)329-36
Antal sider8
ISSN0954-7894
DOI
StatusUdgivet - feb. 2016

ID: 50012945