Abstract
BACKGROUND: Unfavorable conditions associated with cesarean section may influence the risk of type 1 diabetes in offspring, but results from studies are conflicting. We aimed to evaluate the association between prelabor cesarean section and risk of childhood type 1 diabetes.
METHODS: A Danish nationwide cohort study followed all singletons born during 1982-2010. Five national registers provided information on mode of delivery, outcome, and confounders. The risk of childhood type 1 diabetes with onset before the age of 15 years was assessed by Cox regression. A total of 1,760,336 singletons contributed 20,436,684 person-years, during which 4,400 were diagnosed with childhood type 1 diabetes.
RESULTS: The hazard ratio for childhood type 1 diabetes was increased in children delivered by prelabor cesarean section compared with vaginal delivery when adjusted for year of birth, parity, sex, parental age, and education and paternal type 1 diabetes status at childbirth (HR 1.2; 95% CI 1.0 to 1.3), but not after additional adjustment for maternal type 1 diabetes status at childbirth (HR 1.1; 95% CI 0.95 to 1.2). Delivery by intrapartum cesarean section was not associated with childhood type 1 diabetes. Paternal type 1 diabetes was a stronger risk-factor for childhood type 1 (HR 12; 95% CI 10 to 14) than maternal type 1 diabetes (HR 6.5; 95% CI 5.2 to 8.0).
CONCLUSIONS: Delivery by prelabor cesarean section was not associated with an increased risk of childhood type 1 diabetes in the offspring.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Epidemiology (Cambridge, Mass.) |
| Vol/bind | 27 |
| Udgave nummer | 3 |
| Sider (fra-til) | 547-55 |
| ISSN | 1044-3983 |
| DOI | |
| Status | Udgivet - maj 2016 |