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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Prelabor Cesarean Section and Risk of Childhood Type 1 Diabetes - A Nationwide Register-Based Cohort Study

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BACKGROUND: Unfavorable conditions associated with cesarean section may influence the risk of type 1 diabetes in offspring, but results from studies are conflicting. We aimed to evaluate the association between prelabor cesarean section and risk of childhood type 1 diabetes.

METHODS: A Danish nationwide cohort study followed all singletons born during 1982-2010. Five national registers provided information on mode of delivery, outcome, and confounders. The risk of childhood type 1 diabetes with onset before the age of 15 years was assessed by Cox regression. A total of 1,760,336 singletons contributed 20,436,684 person-years, during which 4,400 were diagnosed with childhood type 1 diabetes.

RESULTS: The hazard ratio for childhood type 1 diabetes was increased in children delivered by prelabor cesarean section compared with vaginal delivery when adjusted for year of birth, parity, sex, parental age, and education and paternal type 1 diabetes status at childbirth (HR 1.2; 95% CI 1.0 to 1.3), but not after additional adjustment for maternal type 1 diabetes status at childbirth (HR 1.1; 95% CI 0.95 to 1.2). Delivery by intrapartum cesarean section was not associated with childhood type 1 diabetes. Paternal type 1 diabetes was a stronger risk-factor for childhood type 1 (HR 12; 95% CI 10 to 14) than maternal type 1 diabetes (HR 6.5; 95% CI 5.2 to 8.0).

CONCLUSIONS: Delivery by prelabor cesarean section was not associated with an increased risk of childhood type 1 diabetes in the offspring.

OriginalsprogEngelsk
TidsskriftEpidemiology (Cambridge, Mass.)
Vol/bind27
Udgave nummer3
Sider (fra-til)547-55
ISSN1044-3983
DOI
StatusUdgivet - maj 2016

ID: 46358457