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Region Hovedstaden - en del af Københavns Universitetshospital
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Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years--a prospective study

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  • Birgit Bjerre Høyer
  • Cecilia Høst Ramlau-Hansen
  • Carsten Obel
  • Henning Sloth Pedersen
  • Agnieszka Hernik
  • Victor Ogniev
  • Bo A G Jönsson
  • Christian H Lindh
  • Lars Rylander
  • Anna Rignell-Hydbom
  • Jens Peter Bonde
  • Gunnar Toft
Vis graf over relationer

Abstract


Background

In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5–9 years of age.

Methods

Maternal sera from the INUENDO cohort (2002–2004) comprising 1,106 mother-child pairs from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) were analysed for PFOS and PFOA, using liquid-chromatography-tandem-mass-spectrometry. Exposures were grouped into country specific as well as pooled tertiles as well as being used as continuous variables for statistical analyses. Child motor development and behaviour at follow-up (2010–2012) were measured by the Developmental Coordination Disorder Questionnaire 2007 (DCDQ) and Strength and Difficulties Questionnaire (SDQ), respectively. Exposure-outcome associations were analysed by multiple logistic and linear regression analyses.

Results

In the pooled analysis, odds ratio (OR) (95% confidence interval (CI)) for hyperactivity was 3.1 (1.3, 7.2) comparing children prenatally exposed to the highest PFOA tertile with those exposed to the lowest PFOA tertile. Comparing children in the highest PFOS tertile with those in the lowest PFOS tertile showed elevated but statistically non-significant OR of hyperactivity (OR (95% CI) 1.7 (0.9, 3.2)). In Greenland, elevated PFOS was associated with higher SDQ-total scores indicating more behavioural problems (β (95% CI) =1.0 (0.1, 2.0)) and elevated PFOA was associated with higher hyperactivity sub-scale scores indicating more hyperactive behaviour (β (95% CI) = 0.5 (0.1, 0.9)). Prenatal PFOS and PFOA exposures were not associated with motor difficulties.

Conclusions

Prenatal exposure to PFOS and PFOA may have a small to moderate effect on children’s neuro-behavioural development, specifically in terms of hyperactive behaviour. The associations were strongest in Greenland where exposure contrast is largest.

Keywords:
Behaviour; Child; Child development; Cohort study; Motor development; Perfluorooctanoate (PFOA); Perfluorooctane sulfonate (PFOS); Prenatal exposure, Delayed effects
OriginalsprogEngelsk
TidsskriftEnvironmental Health: A Global Access Science Source
Vol/bind14
Sider (fra-til)2
ISSN1476-069X
DOI
StatusUdgivet - 2015

ID: 45882811