Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pregnancy exposure to bisphenol A and duration of breastfeeding

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Pooled analysis of recent studies of magnetic fields and childhood leukemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Road and railway noise and risk for breast cancer: A nationwide study covering Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The influence of prenatal exposure to phthalates on subsequent male growth and body composition in adolescence

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Exposure to air pollution in early childhood and the association with Attention-Deficit Hyperactivity Disorder

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dynamic changes of reproductive hormones in male minipuberty: Temporal dissociation of Leydig- and Sertoli-cell activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Environmental factors in declining human fertility

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

INTRODUCTION: Bisphenol A (BPA) is frequently used in the production of plastics. It is an endocrine disruptor, and BPA exposure in mice has been associated with reduced offspring growth due to insufficient milk production. However, human studies of associations between BPA exposure and duration of breastfeeding are sparse.

METHODS: Pregnant women from the Odense Child Cohort (n = 725) donated a third trimester morning urine sample, which was analyzed for BPA by LC-MS/MS. Information about duration of exclusive and any breastfeeding was obtained through questionnaires three and 18 months postpartum, and a subgroup of women responded to weekly text messages about breastfeeding. Associations between pregnancy BPA exposure and duration of breastfeeding were analyzed using Cox regression adjusting for potential confounders.

RESULTS: The median urine BPA concentration was 1.29 ng/mL. Compared to women within the lowest tertile of BPA exposure, women in the second and third tertile were slightly more likely to terminate breastfeeding at any given time; HRs (95% CI) were 1.05 (0.87; 1.26) and 1.06 (0.89; 1.27), respectively, and to terminate exclusive breastfeeding at any time up to 20 weeks after birth, HRs (95% CI) were 1.07 (0.88; 1.28) and 1.06 (0.88; 1.27), respectively. However, confidence intervals were also compatible with no effect or even a protective effect.

DISCUSSION: This study indicated that high BPA exposure in pregnancy was associated with shorter duration of breastfeeding. Although our findings were not statistically significant, all estimates were above one suggesting increased risk of early breastfeeding termination with high exposure. Using a single spot morning urine sample to measure BPA has likely caused imprecision as it might not adequately reflect long term exposure. Future studies should consider measuring BPA more than once, including other timepoints during pregnancy and after birth.

OriginalsprogEngelsk
Artikelnummer112471
TidsskriftEnvironmental Research
Vol/bind206
Sider (fra-til)112471
ISSN0013-9351
DOI
StatusUdgivet - 15 apr. 2022

Bibliografisk note

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

ID: 72160329