Pregnancy-associated plasma protein A in non-cardiac conditions

Kasper Karmark Iversen; Ane Sogaard Teisner; Borge Teisner; Anette Kliem; Morten Bay; Vibeke Kirk; Henrik Nielsen; Soren Boesgaard; Peer Grande; Peter Clemmensen

doi:10.1016/j.clinbiochem.2008.01.012

Pregnancy-associated plasma protein A in non-cardiac conditions

Kasper Karmark Iversen, Ane Sogaard Teisner, Borge Teisner, Anette Kliem, Morten Bay, Vibeke Kirk, Henrik Nielsen, Soren Boesgaard, Peer Grande, Peter Clemmensen

16 Citationer (Scopus)

Abstract

OBJECTIVE: PAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease.

DESIGN AND METHODS: PAPP-A was measured within 24 h following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes.

RESULTS: PAPP-A was detectable (> or = 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1-6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p=0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A.

CONCLUSION: PAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease.

Originalsprog	Engelsk
Tidsskrift	Clinical Biochemistry
Vol/bind	41
Udgave nummer	7-8
Sider (fra-til)	548-53
Antal sider	6
ISSN	0009-9120
DOI	https://doi.org/10.1016/j.clinbiochem.2008.01.012
Status	Udgivet - maj 2008

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10.1016/j.clinbiochem.2008.01.012

Citationsformater

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title = "Pregnancy-associated plasma protein A in non-cardiac conditions",

abstract = "OBJECTIVE: PAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease.DESIGN AND METHODS: PAPP-A was measured within 24 h following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes.RESULTS: PAPP-A was detectable (> or = 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1-6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p=0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A.CONCLUSION: PAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease.",

keywords = "Adult, Aged, Biomarkers/blood, Coronary Artery Disease/blood, Female, Humans, Male, Middle Aged, Pregnancy-Associated Plasma Protein-A/analysis",

author = "Iversen, {Kasper Karmark} and Teisner, {Ane Sogaard} and Borge Teisner and Anette Kliem and Morten Bay and Vibeke Kirk and Henrik Nielsen and Soren Boesgaard and Peer Grande and Peter Clemmensen",

year = "2008",

month = may,

doi = "10.1016/j.clinbiochem.2008.01.012",

language = "English",

volume = "41",

pages = "548--53",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier Inc",

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TY - JOUR

T1 - Pregnancy-associated plasma protein A in non-cardiac conditions

AU - Iversen, Kasper Karmark

AU - Teisner, Ane Sogaard

AU - Teisner, Borge

AU - Kliem, Anette

AU - Bay, Morten

AU - Kirk, Vibeke

AU - Nielsen, Henrik

AU - Boesgaard, Soren

AU - Grande, Peer

AU - Clemmensen, Peter

PY - 2008/5

Y1 - 2008/5

N2 - OBJECTIVE: PAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease.DESIGN AND METHODS: PAPP-A was measured within 24 h following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes.RESULTS: PAPP-A was detectable (> or = 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1-6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p=0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A.CONCLUSION: PAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease.

AB - OBJECTIVE: PAPP-A is a promising new marker in coronary heart disease. It is important to investigate its specificity in order to establish its clinical utility as a marker of coronary heart disease.DESIGN AND METHODS: PAPP-A was measured within 24 h following hospital admission in 1448 consecutive patients admitted with diagnoses other than acute coronary syndromes.RESULTS: PAPP-A was detectable (> or = 4.0 mIU/L) in 278 (19.2%) patients, among whom the mean level was 6.3 mIU/L (95% C.I., 6.1-6.5 mIU/L). The 95 and 99 percentiles for PAPP-A were 7.3 and 9.4 mIU/L, respectively. There was no difference in the mean PAPP-A of different diagnoses (p=0.33). None of the specific diagnoses known to influence established coronary markers appeared to influence the level of circulating PAPP-A.CONCLUSION: PAPP-A is low in patients without known coronary heart disease. PAPP-A levels seem to be a potentially highly specific marker for heart disease.

KW - Adult

KW - Aged

KW - Biomarkers/blood

KW - Coronary Artery Disease/blood

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Pregnancy-Associated Plasma Protein-A/analysis

U2 - 10.1016/j.clinbiochem.2008.01.012

DO - 10.1016/j.clinbiochem.2008.01.012

M3 - Journal article

C2 - 18279673

SN - 0009-9120

VL - 41

SP - 548

EP - 553

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 7-8

ER -

Pregnancy-associated plasma protein A in non-cardiac conditions

Abstract

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