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Predictors of adipose tissue concentrations of organochlorine pesticides in a general Danish population

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Bräuner, Elvira V ; Raaschou-Nielsen, Ole ; Gaudreau, Eric ; Leblanc, Alain ; Tjønneland, Anne ; Overvad, Kim ; Sørensen, Mette. / Predictors of adipose tissue concentrations of organochlorine pesticides in a general Danish population. I: Journal of Exposure Science and Environmental Epidemiology. 2011 ; Bind 22, Nr. 1. s. 52-9.

Bibtex

@article{2c6d0a4ffd384a5482a2503522b2edc3,
title = "Predictors of adipose tissue concentrations of organochlorine pesticides in a general Danish population",
abstract = "Organochlorine pesticides are ubiquitously present in the environment and suspected of carcinogenic, neurological and immunological effects. Our objective was to identify determinants of adipose tissue levels of organochlorine pesticides experienced by a general Danish population. Adipose tissue was collected upon enrolment of 245 randomly selected persons from a prospective cohort of 57,053 persons enrolled between 1993 and 1997. We examined geography, gender, age, lactation, body mass index (BMI) and intake of nine dietary groups and tap water drinks, as potential determinants of dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene, hexachlorocyclohexane, dieldrin, hexachlorobenzene, cis-nonachlor, trans-nonachlor and oxychlordane. Living in Copenhagen city and age at enrolment showed positive associations with all compounds. BMI was positively associated with all compounds except cis-nonachlor. Fatty-fish consumption showed positive associations with cis-nonachlor, trans-nonachlor, DDT and dieldrin and fruit and vegetables were inversely associated with dieldrin. Determinant estimates of trans-nonachlor were similar to estimates of total chlordanes while cis-nonachlor and oxychlordane seemed to differ. This is one of the first studies of organochlorine pesticides predictors in adipose tissue and contributes to the ongoing debate about exposure sources of these compounds. Single determinants varied among the individual compounds, even within related chlordane residues, suggesting that organochlorine pesticides should not be treated as a homogenous group.",
keywords = "Adipose Tissue/chemistry, Denmark, Diet Surveys, Environmental Exposure/analysis, Environmental Monitoring, Female, Humans, Hydrocarbons, Chlorinated/analysis, Linear Models, Male, Middle Aged, Multivariate Analysis, Pesticide Residues/analysis, Prospective Studies, Risk Factors, Surveys and Questionnaires",
author = "Br{\"a}uner, {Elvira V} and Ole Raaschou-Nielsen and Eric Gaudreau and Alain Leblanc and Anne Tj{\o}nneland and Kim Overvad and Mette S{\o}rensen",
year = "2011",
month = "11",
day = "3",
doi = "10.1038/jes.2011.39",
language = "English",
volume = "22",
pages = "52--9",
journal = "Journal of Exposure Science and Environmental Epidemiology",
issn = "1559-0631",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Predictors of adipose tissue concentrations of organochlorine pesticides in a general Danish population

AU - Bräuner, Elvira V

AU - Raaschou-Nielsen, Ole

AU - Gaudreau, Eric

AU - Leblanc, Alain

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Sørensen, Mette

PY - 2011/11/3

Y1 - 2011/11/3

N2 - Organochlorine pesticides are ubiquitously present in the environment and suspected of carcinogenic, neurological and immunological effects. Our objective was to identify determinants of adipose tissue levels of organochlorine pesticides experienced by a general Danish population. Adipose tissue was collected upon enrolment of 245 randomly selected persons from a prospective cohort of 57,053 persons enrolled between 1993 and 1997. We examined geography, gender, age, lactation, body mass index (BMI) and intake of nine dietary groups and tap water drinks, as potential determinants of dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene, hexachlorocyclohexane, dieldrin, hexachlorobenzene, cis-nonachlor, trans-nonachlor and oxychlordane. Living in Copenhagen city and age at enrolment showed positive associations with all compounds. BMI was positively associated with all compounds except cis-nonachlor. Fatty-fish consumption showed positive associations with cis-nonachlor, trans-nonachlor, DDT and dieldrin and fruit and vegetables were inversely associated with dieldrin. Determinant estimates of trans-nonachlor were similar to estimates of total chlordanes while cis-nonachlor and oxychlordane seemed to differ. This is one of the first studies of organochlorine pesticides predictors in adipose tissue and contributes to the ongoing debate about exposure sources of these compounds. Single determinants varied among the individual compounds, even within related chlordane residues, suggesting that organochlorine pesticides should not be treated as a homogenous group.

AB - Organochlorine pesticides are ubiquitously present in the environment and suspected of carcinogenic, neurological and immunological effects. Our objective was to identify determinants of adipose tissue levels of organochlorine pesticides experienced by a general Danish population. Adipose tissue was collected upon enrolment of 245 randomly selected persons from a prospective cohort of 57,053 persons enrolled between 1993 and 1997. We examined geography, gender, age, lactation, body mass index (BMI) and intake of nine dietary groups and tap water drinks, as potential determinants of dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene, hexachlorocyclohexane, dieldrin, hexachlorobenzene, cis-nonachlor, trans-nonachlor and oxychlordane. Living in Copenhagen city and age at enrolment showed positive associations with all compounds. BMI was positively associated with all compounds except cis-nonachlor. Fatty-fish consumption showed positive associations with cis-nonachlor, trans-nonachlor, DDT and dieldrin and fruit and vegetables were inversely associated with dieldrin. Determinant estimates of trans-nonachlor were similar to estimates of total chlordanes while cis-nonachlor and oxychlordane seemed to differ. This is one of the first studies of organochlorine pesticides predictors in adipose tissue and contributes to the ongoing debate about exposure sources of these compounds. Single determinants varied among the individual compounds, even within related chlordane residues, suggesting that organochlorine pesticides should not be treated as a homogenous group.

KW - Adipose Tissue/chemistry

KW - Denmark

KW - Diet Surveys

KW - Environmental Exposure/analysis

KW - Environmental Monitoring

KW - Female

KW - Humans

KW - Hydrocarbons, Chlorinated/analysis

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Pesticide Residues/analysis

KW - Prospective Studies

KW - Risk Factors

KW - Surveys and Questionnaires

U2 - 10.1038/jes.2011.39

DO - 10.1038/jes.2011.39

M3 - Journal article

VL - 22

SP - 52

EP - 59

JO - Journal of Exposure Science and Environmental Epidemiology

JF - Journal of Exposure Science and Environmental Epidemiology

SN - 1559-0631

IS - 1

ER -

ID: 57256279