Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Predictive value of plasma hCG measured 14 days after Day-2 single embryo transfer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The impact of cardiovascular diseases on maternal deaths in the Nordic countries

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Assisted reproductive technology treatment and risk of breast cancer: a population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Calcium transport in male reproduction is possibly influenced by vitamin D and CaSR

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Academic performance in adolescents born to mothers with gestational diabetes - a national Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION: Prediction of pregnancy outcome after IVF is important for patients and clinicians. Early plasma hCG (p-hCG) levels are the best known predictor of pregnancy outcome, but no studies has been restricted to single embryo transfer (SET) of Day-2 embryos. The aim of the present study was to investigate the predictive value of p-hCG measured exactly 14 days after the most commonly used Day-2 SET on pregnancy, delivery and perinatal outcome.

MATERIALS AND METHODS: A retrospective analysis of prospectively collected data on 466 women who had p-hCG measured exactly 14 days after Day-2 SET during a randomized trial including 1050 unselected women (aged 18-40 years) undergoing their first IVF/ICSI treatment.

RESULTS: P-hCG predicted clinical pregnancy (AUC 0.953; 95% CI 0.915-0.992) significantly better than ongoing pregnancy (AUC 0.803, 95% CI; 0.717-0.890) and delivery (AUC 0.772, 95% CI; 0.691-0.854). Women with p-hCG levels in the lowest quartile had significantly lower clinical pregnancy, ongoing pregnancy, and delivery rates (p<0.001), whereas the pregnancy outcome and post-clinical pregnancy loss remained similar throughout the three highest p-hCG quartiles. The p-hCG level was neither related to birthweight nor gestational age at delivery.

CONCLUSIONS: Clinical pregnancy is significantly better predicted by p-hCG compared to ongoing pregnancy and delivery. Clinical pregnancy rates, ongoing pregnancy rates and delivery rates remained similar throughout the three highest p-hCG quartiles with no trend towards "the higher the better". This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftActa Obstetricia et Gynecologica Scandinavica
Vol/bind96
Udgave nummer8
Sider (fra-til)960-967
ISSN0001-6349
DOI
StatusUdgivet - 1 aug. 2017

ID: 50179195