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Prediction of preeclampsia in type 1 diabetes in early pregnancy by clinical predictors: a systematic review

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@article{78d137e935d84c93ae017a3f8434fa9c,
title = "Prediction of preeclampsia in type 1 diabetes in early pregnancy by clinical predictors: a systematic review",
abstract = "PURPOSE: The purpose of this study is to evaluate the prevalence and possible clinical predictors of preeclampsia present in early pregnancy among women with type 1 diabetes.METHODS: A systematic search of PubMed was conducted in April 2017. Inclusion criteria were largely unselected cohort, including at least 100 women with type 1 diabetes, dealing with either the prevalence of preeclampsia or possible clinical predictors of preeclampsia identified in early pregnancy.RESULTS: Based on 11,518 pregnancies in 11 articles, the prevalence of preeclampsia in women with type 1 diabetes was 17{\%}, five to six times more than in the background population. In early pregnancy, the following clinical predictors were associated with increased prevalence of preeclampsia: diabetic nephropathy (OR 3.7-23.5), microalbuminuria (OR 3.8-11.7), diabetic retinopathy (OR 1.9-2.9) and pre-existing hypertension (OR 3.8-17.1) as well as high blood pressure within the normotensive range. HbA1C, body mass index and nulliparity were positively associated with preeclampsia, but not consistently.CONCLUSION: The prevalence of preeclampsia in women with type 1 diabetes was 17{\%}. In early pregnancy pre-existing hypertension and high blood pressure within the normotensive range as well as presence of microangiopathy were predictors of preeclampsia. Poor glycaemic control, obesity and nulliparity probably also contribute to the increased risk.",
keywords = "Journal Article, Health Sciences",
author = "Marianne Vestgaard and Sommer, {Miriam Colstrup} and Lene Ringholm and Peter Damm and Mathiesen, {Elisabeth R}",
year = "2018",
month = "6",
doi = "10.1080/14767058.2017.1331429",
language = "English",
volume = "31",
pages = "1933--1939",
journal = "Journal of Maternal-Fetal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "14",

}

RIS

TY - JOUR

T1 - Prediction of preeclampsia in type 1 diabetes in early pregnancy by clinical predictors

T2 - a systematic review

AU - Vestgaard, Marianne

AU - Sommer, Miriam Colstrup

AU - Ringholm, Lene

AU - Damm, Peter

AU - Mathiesen, Elisabeth R

PY - 2018/6

Y1 - 2018/6

N2 - PURPOSE: The purpose of this study is to evaluate the prevalence and possible clinical predictors of preeclampsia present in early pregnancy among women with type 1 diabetes.METHODS: A systematic search of PubMed was conducted in April 2017. Inclusion criteria were largely unselected cohort, including at least 100 women with type 1 diabetes, dealing with either the prevalence of preeclampsia or possible clinical predictors of preeclampsia identified in early pregnancy.RESULTS: Based on 11,518 pregnancies in 11 articles, the prevalence of preeclampsia in women with type 1 diabetes was 17%, five to six times more than in the background population. In early pregnancy, the following clinical predictors were associated with increased prevalence of preeclampsia: diabetic nephropathy (OR 3.7-23.5), microalbuminuria (OR 3.8-11.7), diabetic retinopathy (OR 1.9-2.9) and pre-existing hypertension (OR 3.8-17.1) as well as high blood pressure within the normotensive range. HbA1C, body mass index and nulliparity were positively associated with preeclampsia, but not consistently.CONCLUSION: The prevalence of preeclampsia in women with type 1 diabetes was 17%. In early pregnancy pre-existing hypertension and high blood pressure within the normotensive range as well as presence of microangiopathy were predictors of preeclampsia. Poor glycaemic control, obesity and nulliparity probably also contribute to the increased risk.

AB - PURPOSE: The purpose of this study is to evaluate the prevalence and possible clinical predictors of preeclampsia present in early pregnancy among women with type 1 diabetes.METHODS: A systematic search of PubMed was conducted in April 2017. Inclusion criteria were largely unselected cohort, including at least 100 women with type 1 diabetes, dealing with either the prevalence of preeclampsia or possible clinical predictors of preeclampsia identified in early pregnancy.RESULTS: Based on 11,518 pregnancies in 11 articles, the prevalence of preeclampsia in women with type 1 diabetes was 17%, five to six times more than in the background population. In early pregnancy, the following clinical predictors were associated with increased prevalence of preeclampsia: diabetic nephropathy (OR 3.7-23.5), microalbuminuria (OR 3.8-11.7), diabetic retinopathy (OR 1.9-2.9) and pre-existing hypertension (OR 3.8-17.1) as well as high blood pressure within the normotensive range. HbA1C, body mass index and nulliparity were positively associated with preeclampsia, but not consistently.CONCLUSION: The prevalence of preeclampsia in women with type 1 diabetes was 17%. In early pregnancy pre-existing hypertension and high blood pressure within the normotensive range as well as presence of microangiopathy were predictors of preeclampsia. Poor glycaemic control, obesity and nulliparity probably also contribute to the increased risk.

KW - Journal Article

KW - Health Sciences

U2 - 10.1080/14767058.2017.1331429

DO - 10.1080/14767058.2017.1331429

M3 - Journal article

VL - 31

SP - 1933

EP - 1939

JO - Journal of Maternal-Fetal Medicine

JF - Journal of Maternal-Fetal Medicine

SN - 1476-7058

IS - 14

ER -

ID: 51682426