Prediction of mortality at age 40 in Danish males at high and low risk for alcoholism

J Knop; E C Penick; E L Mortensen; E J Nickel; W F Gabrielli; Per Jensen; S A Mednick

doi:10.1111/j.1600-0447.2004.00393.x

Prediction of mortality at age 40 in Danish males at high and low risk for alcoholism

J Knop, E C Penick, E L Mortensen, E J Nickel, W F Gabrielli, Per Jensen, S A Mednick

6 Citationer (Scopus)

Abstract

OBJECTIVE: This prospective high-risk study examined the influence of father's alcoholism and other archival-generated measures on premature death.

METHOD: Sons of alcoholic fathers (n = 223) and sons of non-alcoholic fathers (n = 106) have been studied from birth to age 40. Archival predictors of premature death included father's alcoholism, childhood developmental data, and diagnostic information obtained from the Psychiatric Register and alcoholism clinics.

RESULTS: By age 40, 21 of the 329 subjects had died (6.4%), a rate that is more than two times greater than expected. Sons of alcoholic fathers were not more likely to die by age 40. Premature death was associated with physical immaturity at 1-year of age and psychiatric/alcoholism treatment. No significant interactions were found between risk and archival measures.

CONCLUSION: Genetic vulnerability did not independently predict death at age 40. Death was associated with developmental immaturities and treatment for a psychiatric and/or substance abuse problem.

Originalsprog	Engelsk
Tidsskrift	Acta Psychiatrica Scandinavica
Vol/bind	110
Udgave nummer	6
Sider (fra-til)	476-82
Antal sider	7
ISSN	0001-690X
DOI	https://doi.org/10.1111/j.1600-0447.2004.00393.x
Status	Udgivet - dec. 2004

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10.1111/j.1600-0447.2004.00393.x

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title = "Prediction of mortality at age 40 in Danish males at high and low risk for alcoholism",

abstract = "OBJECTIVE: This prospective high-risk study examined the influence of father's alcoholism and other archival-generated measures on premature death.METHOD: Sons of alcoholic fathers (n = 223) and sons of non-alcoholic fathers (n = 106) have been studied from birth to age 40. Archival predictors of premature death included father's alcoholism, childhood developmental data, and diagnostic information obtained from the Psychiatric Register and alcoholism clinics.RESULTS: By age 40, 21 of the 329 subjects had died (6.4%), a rate that is more than two times greater than expected. Sons of alcoholic fathers were not more likely to die by age 40. Premature death was associated with physical immaturity at 1-year of age and psychiatric/alcoholism treatment. No significant interactions were found between risk and archival measures.CONCLUSION: Genetic vulnerability did not independently predict death at age 40. Death was associated with developmental immaturities and treatment for a psychiatric and/or substance abuse problem.",

keywords = "Adult, Age Factors, Alcoholism, Cause of Death, Child, Denmark, Fathers, Forecasting, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Registries, Risk Factors, Risk-Taking, Survival Analysis",

author = "J Knop and Penick, {E C} and {L Mortensen}, E and Nickel, {E J} and Gabrielli, {W F} and Per Jensen and Mednick, {S A}",

year = "2004",

month = dec,

doi = "10.1111/j.1600-0447.2004.00393.x",

language = "English",

volume = "110",

pages = "476--82",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Prediction of mortality at age 40 in Danish males at high and low risk for alcoholism

AU - Knop, J

AU - Penick, E C

AU - L Mortensen, E

AU - Nickel, E J

AU - Gabrielli, W F

AU - Jensen, Per

AU - Mednick, S A

PY - 2004/12

Y1 - 2004/12

N2 - OBJECTIVE: This prospective high-risk study examined the influence of father's alcoholism and other archival-generated measures on premature death.METHOD: Sons of alcoholic fathers (n = 223) and sons of non-alcoholic fathers (n = 106) have been studied from birth to age 40. Archival predictors of premature death included father's alcoholism, childhood developmental data, and diagnostic information obtained from the Psychiatric Register and alcoholism clinics.RESULTS: By age 40, 21 of the 329 subjects had died (6.4%), a rate that is more than two times greater than expected. Sons of alcoholic fathers were not more likely to die by age 40. Premature death was associated with physical immaturity at 1-year of age and psychiatric/alcoholism treatment. No significant interactions were found between risk and archival measures.CONCLUSION: Genetic vulnerability did not independently predict death at age 40. Death was associated with developmental immaturities and treatment for a psychiatric and/or substance abuse problem.

AB - OBJECTIVE: This prospective high-risk study examined the influence of father's alcoholism and other archival-generated measures on premature death.METHOD: Sons of alcoholic fathers (n = 223) and sons of non-alcoholic fathers (n = 106) have been studied from birth to age 40. Archival predictors of premature death included father's alcoholism, childhood developmental data, and diagnostic information obtained from the Psychiatric Register and alcoholism clinics.RESULTS: By age 40, 21 of the 329 subjects had died (6.4%), a rate that is more than two times greater than expected. Sons of alcoholic fathers were not more likely to die by age 40. Premature death was associated with physical immaturity at 1-year of age and psychiatric/alcoholism treatment. No significant interactions were found between risk and archival measures.CONCLUSION: Genetic vulnerability did not independently predict death at age 40. Death was associated with developmental immaturities and treatment for a psychiatric and/or substance abuse problem.

KW - Adult

KW - Age Factors

KW - Alcoholism

KW - Cause of Death

KW - Child

KW - Denmark

KW - Fathers

KW - Forecasting

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Longitudinal Studies

KW - Male

KW - Registries

KW - Risk Factors

KW - Risk-Taking

KW - Survival Analysis

U2 - 10.1111/j.1600-0447.2004.00393.x

DO - 10.1111/j.1600-0447.2004.00393.x

M3 - Journal article

C2 - 15521834

SN - 0001-690X

VL - 110

SP - 476

EP - 482

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 6

ER -

Prediction of mortality at age 40 in Danish males at high and low risk for alcoholism

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