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Prediction of coronary heart disease or heart failure using high-sensitivity cardiac troponin T: a pilot study

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@article{ea96c0a1f1b84f27813909cc4ae2b5d0,
title = "Prediction of coronary heart disease or heart failure using high-sensitivity cardiac troponin T: a pilot study",
abstract = "BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is a good prognostic marker for mortality. However, it is uncertain if hs-cTnT can be used to detect sub-clinical cardiac disease.METHOD: Pilot study in patients without known heart disease and elevated hs-cTnT measured at presentation to the emergency department. Hs-cTnT was measure with Roche Diagnostics. Echocardiography was used to assess structural heart disease and the participants underwent computed tomography angiography for assessment of coronary artery disease and agatston score.RESULTS: Ten patients were included in the final cohort. Median age was 68 years IQR (57 - 78) and 80{\%} were female (n=8). Six patients had a history of chronic obstructive lung disease and five patients had history of hypertension. The median level of hs-cTnT was 26 ng/L and values ranged from 19 ng/L - 495 ng/L. The median calcium score was 12. Three patients had signs of coronary artery disease. All patients had normal left ventricular ejection fraction with a median LVEF at 54.5{\%}. Two patients were noted to have increased left ventricular mass index (LVMI).CONCLUSION: The majority of patients with hs-cTnT above the 99th percentile did not have structural heart disease or ischemic coronary disease. However, 30{\%} of the patient did have signs of coronary disease and might benefit from preventive medical treatment. Measuring hs-cTnT in absence of acute illness might be a better approach for evaluation for sub-clinical cardiac disease. This article is protected by copyright. All rights reserved.",
author = "{\'A}sthildur {\'A}rnad{\'o}ttir and Vestergaard, {Kirstine Roll} and Gy{\"o}rgy S{\"o}l{\'e}tormos and Rolf Steffensen and Goetze, {Jens P} and Kasper Iversen",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
doi = "10.1111/eci.13009",
language = "English",
volume = "48",
pages = "e13009",
journal = "European Journal of Clinical Investigation",
issn = "0014-2972",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "10",

}

RIS

TY - JOUR

T1 - Prediction of coronary heart disease or heart failure using high-sensitivity cardiac troponin T

T2 - a pilot study

AU - Árnadóttir, Ásthildur

AU - Vestergaard, Kirstine Roll

AU - Sölétormos, György

AU - Steffensen, Rolf

AU - Goetze, Jens P

AU - Iversen, Kasper

N1 - This article is protected by copyright. All rights reserved.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is a good prognostic marker for mortality. However, it is uncertain if hs-cTnT can be used to detect sub-clinical cardiac disease.METHOD: Pilot study in patients without known heart disease and elevated hs-cTnT measured at presentation to the emergency department. Hs-cTnT was measure with Roche Diagnostics. Echocardiography was used to assess structural heart disease and the participants underwent computed tomography angiography for assessment of coronary artery disease and agatston score.RESULTS: Ten patients were included in the final cohort. Median age was 68 years IQR (57 - 78) and 80% were female (n=8). Six patients had a history of chronic obstructive lung disease and five patients had history of hypertension. The median level of hs-cTnT was 26 ng/L and values ranged from 19 ng/L - 495 ng/L. The median calcium score was 12. Three patients had signs of coronary artery disease. All patients had normal left ventricular ejection fraction with a median LVEF at 54.5%. Two patients were noted to have increased left ventricular mass index (LVMI).CONCLUSION: The majority of patients with hs-cTnT above the 99th percentile did not have structural heart disease or ischemic coronary disease. However, 30% of the patient did have signs of coronary disease and might benefit from preventive medical treatment. Measuring hs-cTnT in absence of acute illness might be a better approach for evaluation for sub-clinical cardiac disease. This article is protected by copyright. All rights reserved.

AB - BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is a good prognostic marker for mortality. However, it is uncertain if hs-cTnT can be used to detect sub-clinical cardiac disease.METHOD: Pilot study in patients without known heart disease and elevated hs-cTnT measured at presentation to the emergency department. Hs-cTnT was measure with Roche Diagnostics. Echocardiography was used to assess structural heart disease and the participants underwent computed tomography angiography for assessment of coronary artery disease and agatston score.RESULTS: Ten patients were included in the final cohort. Median age was 68 years IQR (57 - 78) and 80% were female (n=8). Six patients had a history of chronic obstructive lung disease and five patients had history of hypertension. The median level of hs-cTnT was 26 ng/L and values ranged from 19 ng/L - 495 ng/L. The median calcium score was 12. Three patients had signs of coronary artery disease. All patients had normal left ventricular ejection fraction with a median LVEF at 54.5%. Two patients were noted to have increased left ventricular mass index (LVMI).CONCLUSION: The majority of patients with hs-cTnT above the 99th percentile did not have structural heart disease or ischemic coronary disease. However, 30% of the patient did have signs of coronary disease and might benefit from preventive medical treatment. Measuring hs-cTnT in absence of acute illness might be a better approach for evaluation for sub-clinical cardiac disease. This article is protected by copyright. All rights reserved.

U2 - 10.1111/eci.13009

DO - 10.1111/eci.13009

M3 - Journal article

VL - 48

SP - e13009

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

IS - 10

ER -

ID: 54881791