TY - JOUR
T1 - Prediction of carotid intima-media thickness and its relation to cardiovascular events in persons with type 2 diabetes
AU - Winckler, Karoline
AU - Thorsteinsson, Birger
AU - Wiinberg, Niels
AU - Jensen, Andreas Kryger
AU - Lundby-Christensen, Louise
AU - Heitmann, Berit Lilienthal
AU - Lund, Søren S
AU - Krarup, Thure
AU - Jensen, Tonny
AU - Vestergaard, Henrik
AU - Breum, Leif
AU - Sneppen, Simone
AU - Boesgaard, Trine
AU - Madsbad, Sten
AU - Gluud, Christian
AU - Vaag, Allan
AU - Almdal, Thomas P
AU - Tarnow, Lise
AU - CIMT Trial group
N1 - Copyright © 2020 Elsevier Inc. All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - AIMS: To investigate measures of carotid intima-media thickness (IMT) and conventional cardiovascular (CV) risk factors as predictors of future carotid IMT, and the prediction of CV events during follow-up based on measures of carotid IMT.METHODS: Observational longitudinal study including 230 persons with type 2 diabetes (T2D).RESULTS: Mean age at follow-up was 66.7 (SD 8.5) years, 30.5% were women and mean body mass index (BMI) was 31.8 (4.4) kg/m2. Carotid IMT was measured at baseline, after 18 months of intervention in the Copenhagen Insulin and Metformin Therapy (CIMT) trial and after a mean follow-up of 6.4 (1.0) years. Baseline carotid IMT, carotid IMT after 18 months' intervention, and CV risk factors (age, sex and baseline systolic blood pressure) gave the best prediction of carotid IMT (root mean-squared error of prediction of 0.106 and 95% prediction error probability interval of -0.160, 0.204).CONCLUSIONS: Measures of carotid IMT combined with CV risk factors at baseline predicts attained carotid IMT better than measures of carotid IMT or CV risk factors alone. Carotid IMT did not predict CV events, and the present results do not support the use of carotid IMT as a predictor of CV events in persons with T2D.
AB - AIMS: To investigate measures of carotid intima-media thickness (IMT) and conventional cardiovascular (CV) risk factors as predictors of future carotid IMT, and the prediction of CV events during follow-up based on measures of carotid IMT.METHODS: Observational longitudinal study including 230 persons with type 2 diabetes (T2D).RESULTS: Mean age at follow-up was 66.7 (SD 8.5) years, 30.5% were women and mean body mass index (BMI) was 31.8 (4.4) kg/m2. Carotid IMT was measured at baseline, after 18 months of intervention in the Copenhagen Insulin and Metformin Therapy (CIMT) trial and after a mean follow-up of 6.4 (1.0) years. Baseline carotid IMT, carotid IMT after 18 months' intervention, and CV risk factors (age, sex and baseline systolic blood pressure) gave the best prediction of carotid IMT (root mean-squared error of prediction of 0.106 and 95% prediction error probability interval of -0.160, 0.204).CONCLUSIONS: Measures of carotid IMT combined with CV risk factors at baseline predicts attained carotid IMT better than measures of carotid IMT or CV risk factors alone. Carotid IMT did not predict CV events, and the present results do not support the use of carotid IMT as a predictor of CV events in persons with T2D.
KW - Ageing
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Cardiovascular risk factors
KW - Carotid intima-media thickness
KW - Prediction
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85088931861&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2020.107681
DO - 10.1016/j.jdiacomp.2020.107681
M3 - Journal article
C2 - 32741659
SN - 1056-8727
VL - 34
SP - 107681
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 10
M1 - 107681
ER -