Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Predicted risk of stroke and bleeding and use of oral anticoagulants in atrial fibrillation: Danish nationwide temporal trends 2011-2016

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Candidate single nucleotide polymorphisms and thromboembolism in acute lymphoblastic leukemia - A NOPHO ALL2008 study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Role of spleen and liver for enhanced hemostatic competence following administration of adrenaline to humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Managing antiphospholipid syndrome in pregnancy

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Venous thromboembolism in epithelial ovarian cancer. A prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Time in therapeutic range and risk of thromboembolism and bleeding in patients with a mechanical heart valve prosthesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Socioeconomic position and one-year mortality risk among patients with heart failure: A nationwide register-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ischaemic heart disease, infection, and treatment of infection

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Diagnostic Potential of Intracardiac Echocardiography in Patients with Suspected Prosthetic Valve Endocarditis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Incidence of heart failure after pacemaker implantation: a nationwide Danish Registry-based follow-up study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION, MATERIALS AND METHODS: We used Danish nationwide registries to examine temporal trends in the predicted stroke and bleeding risks (mean CHA2DS2-VASc and HAS-BLED scores per year, respectively) as well as the combination of selected stroke and bleeding risk factors per year among atrial fibrillation (AF) patients initiated for the first time between 2011 and 2016 on vitamin K antagonists (VKAs), dabigatran, rivaroxaban, or apixaban.

RESULTS: In total, 53,860 AF patients were included (VKA 37.7%, dabigatran 24.4%, rivaroxaban 16.9%, apixaban 21.0%). For standard dose dabigatran initiators, during almost all of the study period, the mean CHA2DS2-VASc and HAS-BLED scores were the lowest and decreased (2.6 and 2.2 in 2011 vs. 2.1 and 1.8 in 2016, respectively). Reduced dose apixaban initiators had rather stable mean CHA2DS2-VASc scores during the study period and the highest mean CHA2DS2-VASc score in 2016 (4.1). The mean HAS-BLED scores were similarly high among reduced dose apixaban and rivaroxaban initiators in years 2013-2016. From 2011 to 2014, a decrease in the frequency of prior stroke (p<0.001), age≥75years (p<0.001), and prior bleeding (p=0.007) was observed among dabigatran initiators. In the study period, apixaban initiators in general had the highest frequency of prior stroke and age≥75years.

CONCLUSIONS: Danish AF patients receiving standard dose dabigatran had the lowest and decreasing predicted stroke and bleeding risks during almost all study years. Patients receiving reduced dose apixaban had rather stable predicted risk of stroke during the study period and the highest mean CHA2DS2-VASc score in 2016.

OriginalsprogEngelsk
TidsskriftThrombosis Research
Vol/bind160
Sider (fra-til)19-26
Antal sider8
ISSN0049-3848
DOI
StatusUdgivet - dec. 2017

ID: 52410378