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PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells

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Thoren, Lina A ; Fog, Cathrine K ; Jensen, Klaus Thorleif ; Buza-Vidas, Natalija ; Côme, Christophe Roger Michel ; Lund, Anders H. ; Porse, Bo T. / PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells. I: Stem Cell Research. 2013 ; Bind 11, Nr. 3. s. 1129-1136.

Bibtex

@article{e50ac22eae0f49458e69ab9b54b73789,
title = "PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells",
abstract = "Hematopoietic stem cells (HSC)(1) supply organisms with life-long output of mature blood cells. To do so, the HSC pool size has to be maintained by HSC self-renewing divisions. PRDM3 and PRDM16 have been documented to regulate HSC self-renewal, maintenance and function. We found Prdm11 to have similar expression patterns in the hematopoietic stem and progenitor cell (HSPC) compartments as Prdm3 and Prdm16. Therefore, we undertook experiments to test if PRDM11 regulates HSC self-renewal, maintenance and function by investigating the Prdm11(-/-) mice. Our data shows that phenotypic HSPCs are intact in bone marrow (BM) of one-year-old Prdm11(-/-) mice. In addition, Prdm11(-/-) mice were able to fully regenerate the hematopoietic system upon BM transplantation (BMT) into lethally irradiated mice with a mild drop in lymphoid output only. Taken together, this suggests that PRDM11, in contrast to PRDM3 and PRDM16, is not directly involved in regulation of HSPCs in mice.",
author = "Thoren, {Lina A} and Fog, {Cathrine K} and Jensen, {Klaus Thorleif} and Natalija Buza-Vidas and C{\^o}me, {Christophe Roger Michel} and Lund, {Anders H.} and Porse, {Bo T}",
note = "{\circledC} 2013.",
year = "2013",
month = "8",
day = "9",
doi = "10.1016/j.scr.2013.07.009",
language = "English",
volume = "11",
pages = "1129--1136",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells

AU - Thoren, Lina A

AU - Fog, Cathrine K

AU - Jensen, Klaus Thorleif

AU - Buza-Vidas, Natalija

AU - Côme, Christophe Roger Michel

AU - Lund, Anders H.

AU - Porse, Bo T

N1 - © 2013.

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Hematopoietic stem cells (HSC)(1) supply organisms with life-long output of mature blood cells. To do so, the HSC pool size has to be maintained by HSC self-renewing divisions. PRDM3 and PRDM16 have been documented to regulate HSC self-renewal, maintenance and function. We found Prdm11 to have similar expression patterns in the hematopoietic stem and progenitor cell (HSPC) compartments as Prdm3 and Prdm16. Therefore, we undertook experiments to test if PRDM11 regulates HSC self-renewal, maintenance and function by investigating the Prdm11(-/-) mice. Our data shows that phenotypic HSPCs are intact in bone marrow (BM) of one-year-old Prdm11(-/-) mice. In addition, Prdm11(-/-) mice were able to fully regenerate the hematopoietic system upon BM transplantation (BMT) into lethally irradiated mice with a mild drop in lymphoid output only. Taken together, this suggests that PRDM11, in contrast to PRDM3 and PRDM16, is not directly involved in regulation of HSPCs in mice.

AB - Hematopoietic stem cells (HSC)(1) supply organisms with life-long output of mature blood cells. To do so, the HSC pool size has to be maintained by HSC self-renewing divisions. PRDM3 and PRDM16 have been documented to regulate HSC self-renewal, maintenance and function. We found Prdm11 to have similar expression patterns in the hematopoietic stem and progenitor cell (HSPC) compartments as Prdm3 and Prdm16. Therefore, we undertook experiments to test if PRDM11 regulates HSC self-renewal, maintenance and function by investigating the Prdm11(-/-) mice. Our data shows that phenotypic HSPCs are intact in bone marrow (BM) of one-year-old Prdm11(-/-) mice. In addition, Prdm11(-/-) mice were able to fully regenerate the hematopoietic system upon BM transplantation (BMT) into lethally irradiated mice with a mild drop in lymphoid output only. Taken together, this suggests that PRDM11, in contrast to PRDM3 and PRDM16, is not directly involved in regulation of HSPCs in mice.

U2 - 10.1016/j.scr.2013.07.009

DO - 10.1016/j.scr.2013.07.009

M3 - Journal article

VL - 11

SP - 1129

EP - 1136

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

IS - 3

ER -

ID: 40037743