Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial

Stephen D Wiviott; Harvey D White; E Magnus Ohman; Keith A A Fox; Paul W Armstrong; Dorairaj Prabhakaran; Gail Hafley; Yuliya Lokhnygina; William E Boden; Christian Hamm; Peter Clemmensen; Jose C Nicolau; Alberto Menozzi; Witold Ruzyllo; Petr Widimsky; Ali Oto; Jose Leiva-Pons; Gregory Pavlides; Kenneth J Winters; Matthew T Roe; Deepak L Bhatt

doi:10.1016/S0140-6736(13)61451-8

Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial

Stephen D Wiviott, Harvey D White, E Magnus Ohman, Keith A A Fox, Paul W Armstrong, Dorairaj Prabhakaran, Gail Hafley, Yuliya Lokhnygina, William E Boden, Christian Hamm, Peter Clemmensen, Jose C Nicolau, Alberto Menozzi, Witold Ruzyllo, Petr Widimsky, Ali Oto, Jose Leiva-Pons, Gregory Pavlides, Kenneth J Winters, Matthew T RoeDeepak L Bhatt

103 Citationer (Scopus)

Abstract

Treatment with prasugrel and aspirin improves outcomes compared with clopidogrel and aspirin for patients with acute coronary syndrome who have had angiography and percutaneous coronary intervention; however, no clear benefit has been shown for patients managed first with drugs only. We assessed outcomes from the TRILOGY ACS trial based on whether or not patients had coronary angiography before treatment was chosen.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	382
Udgave nummer	9892
Sider (fra-til)	605-13
Antal sider	9
ISSN	0140-6736
DOI	https://doi.org/10.1016/S0140-6736(13)61451-8
Status	Udgivet - 17 aug. 2013

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Wiviott, S. D., White, H. D., Ohman, E. M., Fox, K. A. A., Armstrong, P. W., Prabhakaran, D., Hafley, G., Lokhnygina, Y., Boden, W. E., Hamm, C., Clemmensen, P., Nicolau, J. C., Menozzi, A., Ruzyllo, W., Widimsky, P., Oto, A., Leiva-Pons, J., Pavlides, G., Winters, K. J., ... Bhatt, D. L. (2013). Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial. Lancet, 382(9892), 605-13. https://doi.org/10.1016/S0140-6736(13)61451-8

Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial. / Wiviott, Stephen D; White, Harvey D; Ohman, E Magnus et al.
I: Lancet, Bind 382, Nr. 9892, 17.08.2013, s. 605-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Wiviott, SD, White, HD, Ohman, EM, Fox, KAA, Armstrong, PW, Prabhakaran, D, Hafley, G, Lokhnygina, Y, Boden, WE, Hamm, C, Clemmensen, P, Nicolau, JC, Menozzi, A, Ruzyllo, W, Widimsky, P, Oto, A, Leiva-Pons, J, Pavlides, G, Winters, KJ, Roe, MT & Bhatt, DL 2013, 'Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial', Lancet, bind 382, nr. 9892, s. 605-13. https://doi.org/10.1016/S0140-6736(13)61451-8

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abstract = "Treatment with prasugrel and aspirin improves outcomes compared with clopidogrel and aspirin for patients with acute coronary syndrome who have had angiography and percutaneous coronary intervention; however, no clear benefit has been shown for patients managed first with drugs only. We assessed outcomes from the TRILOGY ACS trial based on whether or not patients had coronary angiography before treatment was chosen.",

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T2 - a secondary, prespecified analysis of the TRILOGY ACS trial

AU - Wiviott, Stephen D

AU - White, Harvey D

AU - Ohman, E Magnus

AU - Fox, Keith A A

AU - Armstrong, Paul W

AU - Prabhakaran, Dorairaj

AU - Hafley, Gail

AU - Lokhnygina, Yuliya

AU - Boden, William E

AU - Hamm, Christian

AU - Clemmensen, Peter

AU - Nicolau, Jose C

AU - Menozzi, Alberto

AU - Ruzyllo, Witold

AU - Widimsky, Petr

AU - Oto, Ali

AU - Leiva-Pons, Jose

AU - Pavlides, Gregory

AU - Winters, Kenneth J

AU - Roe, Matthew T

AU - Bhatt, Deepak L

PY - 2013/8/17

Y1 - 2013/8/17

N2 - Treatment with prasugrel and aspirin improves outcomes compared with clopidogrel and aspirin for patients with acute coronary syndrome who have had angiography and percutaneous coronary intervention; however, no clear benefit has been shown for patients managed first with drugs only. We assessed outcomes from the TRILOGY ACS trial based on whether or not patients had coronary angiography before treatment was chosen.

AB - Treatment with prasugrel and aspirin improves outcomes compared with clopidogrel and aspirin for patients with acute coronary syndrome who have had angiography and percutaneous coronary intervention; however, no clear benefit has been shown for patients managed first with drugs only. We assessed outcomes from the TRILOGY ACS trial based on whether or not patients had coronary angiography before treatment was chosen.

KW - Acute Coronary Syndrome

KW - Aged

KW - Angina, Unstable

KW - Coronary Angiography

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Piperazines

KW - Platelet Aggregation Inhibitors

KW - Risk Factors

KW - Stroke

KW - Thiophenes

KW - Ticlopidine

KW - Treatment Outcome

UR - https://www.scopus.com/pages/publications/84882265903

U2 - 10.1016/S0140-6736(13)61451-8

DO - 10.1016/S0140-6736(13)61451-8

M3 - Journal article

C2 - 23953385

SN - 0140-6736

VL - 382

SP - 605

EP - 613

JO - Lancet

JF - Lancet

IS - 9892

ER -

Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial

Abstract

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