Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme

Mirabella Zhao; Mads Damsgaard Wewer; Jacob Tveiten Bjerrum; Casper Steenholdt; Frank Schiødt; Kent Haderslev; Marianne Kiszka-Kanowitz; Pia Munkholm; Jakob Seidelin; Johan Burisch

Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme

Mirabella Zhao, Mads Damsgaard Wewer, Jacob Tveiten Bjerrum, Casper Steenholdt, Frank Schiødt, Kent Haderslev, Marianne Kiszka-Kanowitz, Pia Munkholm, Jakob Seidelin, Johan Burisch^*

^*Corresponding author af dette arbejde

Abstract

Despite the increasing availability of biological treatment in recent years, thiopurines remain an important treatment option in patients with inflammatory bowel diseases (IBD) both as monotherapy and in combination therapy with biologicals. Pre-treatment screening of thiopurine-methyltransferase activity and monitoring of thiopurine metabolites during treatment are essential to optimize the effectiveness and safety of thiopurines. This review provides an evidence-based practical guide to prescribing and monitoring thiopurines in patients with IBD.

Bidragets oversatte titel	Practical guide to the use of thiopurinesin patients with inflammatory bowel diseases
Originalsprog	Dansk
Artikelnummer	V09210706
Tidsskrift	Ugeskrift for Laeger
Vol/bind	184
Udgave nummer	11
Sider (fra-til)	1-9
Antal sider	9
ISSN	0041-5782
Status	Udgivet - 14 mar. 2022

Emneord

Humans
Immunologic Factors
Inflammatory Bowel Diseases/drug therapy
Mercaptopurine/adverse effects

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https://ugeskriftet.dk/files/scientific_article_files/2022-03/v09210706_web.pdf

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Citationsformater

Zhao, M., Wewer, M. D., Bjerrum, J. T., Steenholdt, C., Schiødt, F., Haderslev, K., Kiszka-Kanowitz, M., Munkholm, P., Seidelin, J., & Burisch, J. (2022). Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme. Ugeskrift for Laeger, 184(11), 1-9. Artikel V09210706. https://ugeskriftet.dk/files/scientific_article_files/2022-03/v09210706_web.pdf

Zhao, M, Wewer, MD, Bjerrum, JT, Steenholdt, C , Schiødt, F , Haderslev, K , Kiszka-Kanowitz, M , Munkholm, P , Seidelin, J & Burisch, J 2022, 'Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme', Ugeskrift for Laeger, bind 184, nr. 11, V09210706, s. 1-9. <https://ugeskriftet.dk/files/scientific_article_files/2022-03/v09210706_web.pdf>

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abstract = "Despite the increasing availability of biological treatment in recent years, thiopurines remain an important treatment option in patients with inflammatory bowel diseases (IBD) both as monotherapy and in combination therapy with biologicals. Pre-treatment screening of thiopurine-methyltransferase activity and monitoring of thiopurine metabolites during treatment are essential to optimize the effectiveness and safety of thiopurines. This review provides an evidence-based practical guide to prescribing and monitoring thiopurines in patients with IBD.",

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author = "Mirabella Zhao and Wewer, {Mads Damsgaard} and Bjerrum, {Jacob Tveiten} and Casper Steenholdt and Frank Schi{\o}dt and Kent Haderslev and Marianne Kiszka-Kanowitz and Pia Munkholm and Jakob Seidelin and Johan Burisch",

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AU - Wewer, Mads Damsgaard

AU - Bjerrum, Jacob Tveiten

AU - Steenholdt, Casper

AU - Schiødt, Frank

AU - Haderslev, Kent

AU - Kiszka-Kanowitz, Marianne

AU - Munkholm, Pia

AU - Seidelin, Jakob

AU - Burisch, Johan

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AB - Despite the increasing availability of biological treatment in recent years, thiopurines remain an important treatment option in patients with inflammatory bowel diseases (IBD) both as monotherapy and in combination therapy with biologicals. Pre-treatment screening of thiopurine-methyltransferase activity and monitoring of thiopurine metabolites during treatment are essential to optimize the effectiveness and safety of thiopurines. This review provides an evidence-based practical guide to prescribing and monitoring thiopurines in patients with IBD.

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KW - Mercaptopurine/adverse effects

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ER -

Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme

Abstract

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