Despite the increasing availability of biological treatment in recent years, thiopurines remain an important treatment option in patients with inflammatory bowel diseases (IBD) both as monotherapy and in combination therapy with biologicals. Pre-treatment screening of thiopurine-methyltransferase activity and monitoring of thiopurine metabolites during treatment are essential to optimize the effectiveness and safety of thiopurines. This review provides an evidence-based practical guide to prescribing and monitoring thiopurines in patients with IBD.
|Bidragets oversatte titel||Practical guide to the use of thiopurinesin patients with inflammatory bowel diseases|
|Tidsskrift||Ugeskrift for Laeger|
|Status||Udgivet - 14 mar. 2022|
- Immunologic Factors
- Inflammatory Bowel Diseases/drug therapy
- Mercaptopurine/adverse effects